Isolation and Hypoglycemic Activity of Ephedrans A, B, C, D and E, Glycans of Ephedra distachya Herbs1. |
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| Authors: | C Konno T Mizuno H Hikino |
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| Affiliation: | Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan. |
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| Abstract: | Administration of an aqueous methanol/water extract of the Oriental crude drug "maō" (Ephedra), EPHEDRA DISTACHYA herbs, caused transient hyperglycemia followed by long lasting hypoglycemia in mice. Activity-guided fractionation of the extract led to isolation of five glycans, ephedrans A, B, C, D and E, which exhibited significant hypoglycemic effects in normal and alloxan-induced hyperglycemic mice. |
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