CD105在口腔鳞癌中表达及与病理特征和预后相关性研究

目的 检测口腔鳞癌(oral squamous cell carcinoma，OSCC)组织中CD105的表达，并探讨CD105与口腔鳞癌临床病理特征和预后之间的相关性。方法 采用免疫组化(SP)方法，用抗CD105抗体分别标记正常黏膜组织和鳞癌组织中的血管内皮细胞，测定微血管密度（MVD），并分析CD105-MVD与口腔鳞癌临床病理特征及预后的相关性。结果 CD105在病变组织中的表达与正常组织有明显差异（P＜0.05）；OSCC组织中，CD105-MVD高表达率与分化程度、临床分期、T分类、淋巴结转移密切相关，差异有统计学意义（P＜0.05）；与年龄、性别、吸烟无关（P≥0.05）；CD105-MVD高表达组患者五年生存率低于CD105-MVD低表达组生存率，两者间差异有统计学意义（P＜0.05）。结论 CD105与年龄、性别、吸烟与否无明显相关性；与OSCC的病理分级、临床分期、T分类、淋巴结转移有关;CD105高表达组患者预后差，可以作为OSCC预后的参考指标之一。

Expression of CD105 and its correlations with pathologic characteristics and prognosis in oral squamous cell carcinoma

Objective To investigate the expression of CD105 in oral squamous cell carcinoma (OSCC) and to probe into CD105′s correlations with the pathological characteristics and prognosis in OSCC.Methods Immunohistochemistry was used to mark vascular endothelial cells in the normal tissue group and OSCC tissue groups by anti CD105 antibody,to measure MVD (Microvessel Density),and to analyze the correlations between CD105 MVD and the pathological characteristics and prognosis in OSCC.Results A positive stain of CD105 was observed in OSCC,which significantly differed from the normal tissue group (P＜0.05); In the OSCC tissue group,the expression of CD105 was associated with the degree of differentiation,clinical stage,T classification and lymph node metastasis (P＜0.05),but not with age,sex or smoking（P≥0.05).Besides,the five year survival rates of patients with high CD105 MVD were lower than that of patients with low CD105 MVD (P＜0.05).Conclusions CD105 has no correlation with age,sex or smoking,but has a relationship with the degree of differentiation,clinical stage,T classification,lymph node metastasis and prognosis in OSCC.Besides,the low survival rates of patients with high CD105 MVD can be referred to as an index of prognosis.