| Nitric Oxide Synthase Activity in Arterial Tissues ofCirrhotic Rats |
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| 引用本文： | 张丕利,梁扩寰,林菊生,王天才,杜荔菁. Nitric Oxide Synthase Activity in Arterial Tissues ofCirrhotic Rats[J]. 华中科技大学学报(医学英德文版), 1997, 17(1): 25-27. DOI: 10.1007/BF02887997 |
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| 作者姓名： | 张丕利 梁扩寰 林菊生 王天才 杜荔菁 |
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| 作者单位： | Institute of Liver Diseases，Tongji Hospital，Tongj Medical University，Wuhan 430030 |
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| 摘 要： | Studiesonthestatusofhemodynamiccirculationincirrhoticportalhypertensionindicatedacloserelationshipwithprognosisofthedisease.Theretof0re,vasodilatorsbecamethefocusofstudiesinrecentyears['J.lthadbeenfoundthattheserumconcentrationsofglyc0gen,prostacycl1n,cholicacidetc.wereallincreasedincirrh0t-icportalhypertension,andwereinvolvedlnperipheralarterialdilatati0n[2]-Vallenceproposedthatincreaseofnitricoxide(NO)andsynthase(NOS)inthevascularen-dotheliumincirrh0slswasprobablyrelatedtothehemodynamlcdis…
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| 收稿时间： | 1996-04-20 |
Nitric oxide synthase activity in arterial tissues of cirrhotic rats |
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| Zhang Pili,Liang Kuohuan,Lin Jusheng,Wang Tiancai,Du Lijing. Nitric oxide synthase activity in arterial tissues of cirrhotic rats[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1997, 17(1): 25-27. DOI: 10.1007/BF02887997 |
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| Authors: | Zhang Pili Liang Kuohuan Lin Jusheng Wang Tiancai Du Lijing |
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| Affiliation: | (1) Institute of Liver Diseases, Tongji Hospital, Tongji Medical University, 430030 Wuhan;(2) Present address: Shanghai First People’s Hospital, 200080 Shanghai |
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| Abstract: | The changes in the activities of constitutive nitric oxide (NO) synthase (cNOS) and inducible NOS (iNOS) were investigated in arterial tissues of CCl4induced cirrhotic adult SD rats- The aortic tissue homogenate were prepared in normal and cirrhotic rats. NOS activity was measured by conversion of 3H-arginine to H-citrulline. The activities of cNOS and iNOS were calculated in terms of presence or absence of Ca2 . The results showed that activities of total NOS,cNOS and iNOS in arterial tissues were all increased significantly in cirrhotic rats as compared with those in normal controls. There was a significant positive correlation between the activities of total NOS and cGMP content in cirrhotic arterial tissues. |
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| Keywords: | nitric oxide synthase arterial tissue cirrhosis rats |
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