| 脆弱性组氨酸三联体表达与非小细胞肺癌的关系 |
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| 引用本文： | 高进,郭妍妍,李秀霞. 脆弱性组氨酸三联体表达与非小细胞肺癌的关系[J]. 中国基层医药, 2006, 13(1): 109-110 |
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| 作者姓名： | 高进 郭妍妍 李秀霞 |
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| 作者单位： | 010050,内蒙古呼和浩特,内蒙古医学院第一附属医院儿科 |
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| 摘 要： | 目的 研究脆弱性组氨酸三联体（FHIT）的表达与非小细胞肺癌（NSCLC）的发生发展及与吸烟的关系。方法 采用免疫组化（S-P）法检测7例正常支气管黏膜和81例NSCLC患者中FHIT的表达。结果 FHIT在正常支气管黏膜及NSCLC中的表达差异有显著意义（P〈0．05），其表达与分化程度、吸烟指数及吸烟率差异有显著意义（P〈0．01，P〈0．05，P〈0．05），与性别、年龄、TNM分期及分型无关。吸烟与鳞癌星正相关。结论 FHIT是NSCLC发生发展分子机制之一；FHIT可能与烟草致癌有相关性。
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| 关 键 词： | 组氨酸 吸烟 非小细胞肺癌 脆弱性组氨酸三联体 免疫组化 |
| 收稿时间： | 2005-05-30 |
| 修稿时间： | 2005-05-30 |
The expression of FHIT and the relativity with cigarette in NSCLC |
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| GAO Jin,GUO Yan-yan,Li Xiu-xia. The expression of FHIT and the relativity with cigarette in NSCLC[J]. Chinese Journal of Primary Medicine and Pharmacy, 2006, 13(1): 109-110 |
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| Authors: | GAO Jin GUO Yan-yan Li Xiu-xia |
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| Affiliation: | Department of Pediatrics, First Affiliated Hospital, Inner Mongolia Medical College, Huhehaote , Neimenggu ,010050, China |
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| Abstract: | Objective To investigate the role of FHIT in NSCLC and the relativity between FHIT and cigarette.Methods 81 cases of NSCLC and 7 cases of the nomal lung tisses were examined for FHIT by immunochemical(S-P).Results The postive expression rates of FHIT were significantly lower than those in nomal lung tisses(P<0.05).The expression rates of FHIT were correlated with degree of differentiation of NSCLC and smoking index,smoking rate(P<0.01,P<0.05,P<0.05),there were no relativity with TNM stage,age,sex and histology.There were the relativity between smoking history and squamous cell.Conclusions FHIT is one of events in NSCLC.FHIT may be relativited with NSCLC produced by smoking. |
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| Keywords: | Histidine Carcinoma, non-small-cell lung Smoklng |
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