| 血小板衍生生长因子及其受体与病毒性肝炎肝纤维化 … |
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| 引用本文： | 辛绍杰,赵景民.血小板衍生生长因子及其受体与病毒性肝炎肝纤维化 …[J].中华实验和临床病毒学杂志,1998,12(1):51-53. |
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| 作者姓名： | 辛绍杰 赵景民 |
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| 摘 要： | 目的 研究血小板衍生生长因子在病毒性肝炎肝纤维化中的作用。方法 以免疫组化技术检测血小板衍生生长因子（ＰＤＧＦ）－ＢＢ以及ＰＤＧＦ的β受体（ＰＤＧＦＲ－β）在病毒性肝炎肝组织中的表达。结果 ＰＤＧＦ－ＢＢ及ＰＤＧＦＲ－β在肝组织中的表达与肝纤维化程度明显相关，肝硬变及慢性肝炎Ｓ３￣４期患者肝组织ＰＤＧＦ－ＢＢ及ＰＤＧＦＲ－β表达强度明显高于急性肝炎及慢性肝炎Ｓ０￣２期患者，同时与结蛋白、Ⅲ型前胶原
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| 关 键 词： | 病毒性肝炎 肝纤维化 PDGF PDGFR－β |
Study on relationship of the expression of platelet-derived growth factor and its receptor-beta in liver tissues with liver fibrosis] |
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| S Xin,J Zhao,L Wang.Study on relationship of the expression of platelet-derived growth factor and its receptor-beta in liver tissues with liver fibrosis][J].Chinese Journal of Experimental and Clinical Virology,1998,12(1):51-53. |
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| Authors: | S Xin J Zhao L Wang |
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| Institution: | 302 Hospital of PLA, Beijing 100039. |
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| Abstract: | The expression of platelet-derived growth factor(PDGF)-BB and PDGF receptor-beta(PDGFR-beta) in liver tissues from viral hepatitis was detected by immunohistochemistry. The results showed that the expression of PDGF-BB and PDGFR-beta in the liver tissues correlated closely with the degree of liver fibrosis. The levels of their expression in the liver cirrhosis and fibrosis stage S3-4 of chronic viral hepatitis(CH) were much higher than those in acute viral hepatitis and fibrosis stage S0-2 of CH. Meanwhile, the expression of PDGF and its receptor was associated with the expression of desmin-positive cells pro-collagen III peptide in liver tissues and tissue inhibitor of metalloprotenase-1 in serum. It is suggested that PDGF-BB and its receptor-beta may promote the progress of liver fibrosis by means of the activation, proliferation and differentiation of satellite cells. |
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