首页 | 本学科首页   官方微博 | 高级检索  
     


Cyclosporine in the treatment of azathioprine-induced red cell aplasia following renal transplantation
Authors:Beth Vogt  Barbara A. Fivush
Affiliation:(1) Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;(2) Pediatric Kidney Center, Park 207, Johns Hopkins Hospital, 600 N. Wolfe Street, 21205 Baltimore, MD, USA
Abstract:Azathioprine, a well-known immunosuppressive agent, is used extensively in renal transplantation. There have been several case reports of pure red cell aplasia induced by this drug following a successful kidney transplant. Previous management of azathioprine-induced red cell aplasia included reduction of azathioprine dose, or treatment with cyclophosphamide. We propose the substitution of cyclosporine for azathioprine, in this clinical setting. Not only does cyclosporine allow recovery of bone marrow function, but it maintains a level of immunosuppression which stabilizes renal function in the post-transplant patient.
Keywords:Red cell aplasia  Azathioprine  Cyclosporine  Renal transplantation  Immunosuppression
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号