Effects of new bisphosphonic acids on tumor-induced bone destruction in the rat |
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| Authors: | Franz Wingen Thomas Eichmann Christian Manegold Burkhard Krempien |
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| Affiliation: | (1) Institute of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 280, D-6900 Heidelberg, Germany;(2) Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-6900 Heidelberg, Germany;(3) Department of Internal Medicine I, University of Heidelberg, Bergheimer Straße, D-6900 Heidelberg, Germany |
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| Abstract: | Summary This report is concerned with therapeutic studies utilizing new bisphosphonic acids on tumor-induced osteolytic metastases. The bone metastases on SD rats were induced by intraarterial and intraosseous transplantation of Walker carcinosarcoma 256B ascites cells. The treatment was carried out using disodium-3-amino-1-hydroxypropylidene-1,1-bisphophonate (APD), diglycidyl-[3-(3,3-bisphosphono-3-hydroxy-propylamino)-2-hydroxypropyl-]urazol-Na2 (DDU) and 1,2,4-triglycidylurazol (TGU). The extent of bone metastases was determined by X-ray on the 5th and 10th days following tumor inoculation, as well as both microradiographically and histologically upon termination of the experiment.High dose DDU produced a clear reduction of the tumor osteolysis, but these positive results were surpassed using APD. The best results were achieved by pretreatment with APD 24 h prior to tumor inoculation.Dedicated to Professor Dietrich Schmähl on the occasion of his 60th birthday |
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| Keywords: | Bisphosphonic acids Osteolytic metastases Bone metastases |
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