Ischemic colitis and immunosuppression |
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Authors: | Dr Leonard G Gomella MD G Andrew Gehrken MD Patrick F Hagihara MD Robert C Flanigan MD |
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Institution: | (1) Department of Surgery, Division of Urology and General Surgery, Veterans Administration Medical Center, 800 Rose Street, 40536 Lexington, Kentucky;(2) Department of Surgery, Division of Urology and General Surgery, University of Kentucky College of Medicine, Lexington, Kentucky |
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Abstract: | The incidence of ischemic colitis in renal transplant recipients approaches 1 percent. The mortality in these patients with
ischemic colitis is nearly 70 percent. Immunosuppressive agents have been implicated in the development of ischemic colitis.
To study the effect of immunosuppressive agents on ischemic colitis, a 4-cm segment of the colon was devascularized in 27
male Fischer rats. The animals were divided into one control and two treatment groups. One treatment group received methylprednisolone
and the other, azathioprine, in doses similar to those of renal transplant recipients. Both experimental groups, either separately
or combined, showed significantly greater areas of colonic ischemic changes than did the control group. This study demonstrates
that systemic administration of immunosuppressive agents may augment the development of ischemic colitis.
Poster presentation at the meeting of the American Society of Colon and Rectal Surgeons, San Diego, California, May 5 to 10,
1985.
Supported by Biomedical Research Support Grant RR 05374 from the Division of Research Facilities and Resources, NIH. |
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Keywords: | Immunosuppressive agents Ischemic colitis Renal transplantation Ischemic colitis |
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