| 肾综合征出血热双价灭活疫苗免疫原性和安全性观察 |
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| 作者姓名： | Ruan Y Xu X Liu W Deng X Weng S Zhou W Wang Q Chen L Fang L Xu Z Yan Q Liu W Dong G Gu H Yu Y Xu Z |
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| 作者单位： | 上海医科大学流行病学教研室,中国预防医学科学院计划免疫技术指导中心北京市100050,浙江省建德市卫生防疫站,上海医科大学流行病学教研室,上海医科大学流行病学教研室,浙江省建德市卫生防疫站,浙江省建德市卫生防疫站,浙江省建德市卫生防疫站,浙江省建德市卫生防疫站,浙江省建 |
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| 摘 要： | 目的 在肾综合征出血热双价灭活疫苗随机对照试验现场,观察接种人群的免疫效果和副反应发生情况。方法 分别检测１６７ 名和６９ 名基础三针接种者免疫后２ 周血清荧光抗体和中和抗体（Ⅰ和Ⅱ型） ,重点观察６５７ 名接种者免疫后７２ 小时内副反应发生情况。结果 荧光抗体阳转率和几何平均滴度分别为９９．０４％ （１６６／１６７）和２４．５１±２．０６;中和抗体总阳转率为１００ ％ ,其中Ⅰ型为９１．３０％ （６３／６９）、Ⅱ型为８８．４１％（６１／６９） ;中和抗体对Ⅰ型和Ⅱ型几何平均滴度分别为１８．２７±２．２１ 和１２．４７±２．１６ ;接种３ 针疫苗局部反应发生率为１．４８％ ,全身体温反应发生率为０ ．３６ ％ ;未见人群接种后发生严重副反应和异常反应。结论 肾综合征出血热双价灭活疫苗免疫效果良好,接种副反应低。
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| 关 键 词： | 肾综合征性出血热 疫苗 灭活 免疫活性 接种 |
A study on immunogenicity and safety of bivalent inactivated vaccine against hemorrhagic fever with renal syndrome |
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| Ruan Y,Xu X,Liu W,Deng X,Weng S,Zhou W,Wang Q,Chen L,Fang L,Xu Z,Yan Q,Liu W,Dong G,Gu H,Yu Y,Xu Z.A study on immunogenicity and safety of bivalent inactivated vaccine against hemorrhagic fever with renal syndrome[J].Chinese Journal of Preventive Medicine,1999,33(6):340-342. |
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| Authors: | Ruan Y Xu X Liu W Deng X Weng S Zhou W Wang Q Chen L Fang L Xu Z Yan Q Liu W Dong G Gu H Yu Y Xu Z |
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| Institution: | Department of Epidemiology, Shanghai Medical University, Shanghai 200032. |
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| Abstract: | OBJECTIVE: To study side effects and effectiveness of bivalent inactivated vaccine against hemorrhagic fever with renal syndrome in population of a randomized controlled field trial. METHODS: Serum indirect immunofluorescent antibody in 167 persons and neutralization antibody (types I and II) in 69 persons, who received three-dose vaccine, were determined two weeks after immunization, and side effects in 657 vaccinees were observed within 72 houses after immunization. RESULTS: Serum positive conversion rate of indirect immunofluorescent antibody was 99.04% (166/167) with GMT of 24.51 +/- 2.06. Serum positive conversion rate of neutralization antibody was 100% (69/69), 91.30% (63/69) for types I and 88.41% (61/69) for type II, respectively. GMTs for type I and II neutralization antibody were 18.27 +/- 2.21 and 12.47 +/- 2.16, respectively. Side effects at local site vaccinated of the body and temperature rising could be seen in 1.48% and 0.36% of the vaccinees, respectively. No severe side effect and abnormal reaction was found in vaccinees on the field. CONCLUSION: Immune response to bivalent inactivated vaccine against hemorrhagic fever with renal syndrome was satisfactory with slight side effect. |
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| Keywords: | Hemorrhagic fever with renal syndrome Vaccine indctivated Immunity Vaccination |
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