谷胱甘肽转硫酶M1,T1基因型与胃癌易感性的关系

目的　探讨谷胱甘肽转硫酶Ｍ１（ＧＳＴＭ１）、Ｔ１（ＧＳＴＴ１）基因型与胃癌危险性的关系。方法　采用病例对照分子流行病学研究方法和聚合酶链反应技术, 检测９５ 例原发性胃癌病例和９４ 例对照者ＧＳＴＭ１ 和ＧＳＴＴ１ 基因型。结果　ＧＳＴＭ１ 基因缺失［ＧＳＴＭ１（－ ）］ 频率在病例组和对照组分别是６３－１６％ 和４５．７４％ ,差异有显著性（χ２ ＝５ ．７５,Ｐ＝ ０．０１６ ５） ,ＧＳＴＭ１ 基因缺失与胃癌易感性有关（ＯＲ＝ ２．０３,９５％ 可信区间＝１．０９～３．８０ ）。携带ＧＳＴＭ１（ －） 和ＧＳＴＴ１（＋ ）基因型者发生胃癌的危险性显著高于ＧＳＴＭ１（ ＋） 和ＧＳＴＴ１（ －） 基因型携带者,比值比ＯＲ＝２．９１,９５％ 可信区间＝１．０９～７．８９。ＧＳＴＭ１ 基因缺失同时暴露于吸烟者患胃癌的危险性显著增高（ ＯＲ＝ ８．０６ ,９５％ 可信区间＝ ２．８３ ～２３．６７） 。结论　ＧＳＴＭ１ 基因缺失型可增加胃癌发生的危险性。

Relationship between glutathione S-transferase M1, T1 genotype and susceptibility to gastric cancer

OBJECTIVE: The objective of this study was to examine the association between glutathione s-transferase M1, T1 genotype and the risk of gastric cancer. METHODS: A case-control study was carried out and polymerase chain reaction (PCR) technique was used to identify GST M1, GST T1 genotype in 95 cases of primary gastric cancer and 94 controls. RESULTS: The frequency of GST M1 null genotype was 63.16% and 45.74%, respectively in gastric cancer cases and control group, with statistically significant difference (chi(2) = 5.75, P = 0.0165). GST M1 null genotype correlated with the susceptibility to gastric cancer (OR = 2.03, 95% CI of OR = 1.09 - 3.80). The risk for gastric cancer in those with GST M1 null and GST T1 non-null genotype was significantly higher than that in those with GST M1 non-null and GST T1 null genotype, with an OR of 2.91 and 95% CI of ORs 1.09 - 7.89. The risk for gastric cancer in those smoking with GST M1 null genotype increased significantly (OR = 8.06, 95% CI of OR = 2.83 - 23.67). CONCLUSION: GST M1 null genotype was associated with the risk for gastric cancer.