某些血、尿生化指标与妇女骨密度的关系

目的探讨某些血尿生化指标与健康妇女骨密度的关系。方法用单光子骨密度仪测定妇女非优势侧前臂桡骨远端1／10处及中下1／3处骨密度,并测定了空腹10小时后的清晨2小时尿钙（Ca）、尿羟脯氨酸（Hyp）,尿肌酐（Cr）及血清碱性磷酸酶（AKP）含量。结果血清AKP、尿Hyp／Cr随增龄而增加,绝经后更明显,且均与骨密度呈明显负相关。尿Ca／Cr亦随增龄而增加,绝经后更为明显,但与骨密度无明显相关。结论血清AKP、空腹尿Hyp／Cr可作为反映骨转换状态的指标。

Relationship between bone mineral density and blood and urine biochemical indices in women

Objective To study the relationship between bone mineral density (BMD) and some biochemical indices in their blood and urine of women. Methods Fasting urinary calcium (Ca) and creatinine(Cr), ratio of Ca to Cr, urinary hydroxyproline(Hyp), ratio of Hypr to Cr were determined in 163 healthy women, and activity of serum alkaline phosphatase (AKP) were determined in 182 healthy women, BMD at the 1/10 lower endand 1/3 rniddle-lower site of the radius were measured with single photon absorptiometry for all of them. ResultsSerum AKP and ratio of urinary Hyp/Cr increased with age, especially postmenopause, and correlated negativelywith BMD. Fasting urinary Ca/Cr ratio also increased with age, especially postmanopause, but not correlated withBMD. Conclusion Serum AKP and fasting urine Hyp/Cr ratio could be used as indicators to reflect bone remodeling and absorption, respectively.