| 凉山彝族男性血管紧张素转换酶基因多态性与高血压的关系 |
| |
| 作者姓名： | Shan G Wang X Qiu C Ren C Li H Wang P Wu Z Liao S Li X Tong S Zhang K |
| |
| 作者单位： | 中国医学科学院基础医学研究所中国协和医科大学基础医学院流行病学教研室,四川省凉山彝族自治州卫生防疫站,医学分子生物学国家重点实验室,四川省凉山彝族自治州卫生防疫站,中国医学科学院基础医学研究所中国协和医科大学基础医学院流行病学教研室,四川省凉山彝族自治州卫生防 |
| |
| 摘 要： | 目的 探讨血管紧张素转换酶（ＡＣＥ） 基因多态性与高血压的关系。方法 应用横断面调查方法和ＰＣＲ 技术。结果 正常血压人群ＡＣＥ 基因ＤＤ、ＩＤ 和ＩＩ基因型分别占１３ ．０ ％ 、５０ ．９ ％ 和３６ ．１ ％ 。Ｉ和Ｄ等位基因频率分别是为６１ ．６ ％ 和３８ ．４ ％ 。高血压人群ＡＣＥ 基因ＤＤ、ＩＤ 和ＩＩ基因型分别占９ ．７ ％ 、４８ ．４ ％ 和４１ ．９ ％ 。Ｉ和Ｄ 等位基因频率分别是６６ ．１ ％ 和３３ ．９ ％ 。彝族男性高血压和正常血压人群的ＡＣＥ基因型分布及Ｉ／Ｄ 等位基因频率差异无显著性。结论 彝族男性ＡＣＥ 基因多态性与高血压的关联尚不能确定。
|
| 关 键 词： | 少数民族 高血压 肽基二肽酶A 多态现象(遗传学) |
A study on relationship between hypertension and polymorphism of ACE gene in male Yi people in Liangshan Yi autonomous prefecture, Sichuan |
| |
| Shan G,Wang X,Qiu C,Ren C,Li H,Wang P,Wu Z,Liao S,Li X,Tong S,Zhang K.A study on relationship between hypertension and polymorphism of ACE gene in male Yi people in Liangshan Yi autonomous prefecture, Sichuan[J].Chinese Journal of Preventive Medicine,1999,33(6):346-347. |
| |
| Authors: | Shan G Wang X Qiu C Ren C Li H Wang P Wu Z Liao S Li X Tong S Zhang K |
| |
| Institution: | Department of Epidemiology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005. |
| |
| Abstract: | Objective To explore relationship between polymorphism of ACE gene and hypertension. Methods A cross sectional study was conducted and PCR technique was used to analyze gene polymorphism. Results Genotypes DD, ID and II of ACE gene accounted for 13.0% and 9.7%,50.9% and 48.4%, and 36.1% and 41.9%, respectively, in the normotensives and hypertensives. Frequencies of I and D alleles for ACE gene were 61.6% and 66.1%, and 38.4% and 33.9%, respectively, in the normotensives and hypertensives. There was no significant difference in distribution of II, ID and DD genotypes and I/D allele frequencies of ACE gene between the hypertensives and normotensives in male Yi people. Conclusion Association between polymorphism of ACE gene and hypertension was uncertain. |
| |
| Keywords: | Minority groups Hypertension Peotidyl dipeptidase A Polymorphism (genetics) |
| 本文献已被 CNKI 维普 PubMed 等数据库收录！ |
|
