Multiply resistant Haemophilus influenzae type b causing meningitis: comparative clinical and laboratory study |
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| Authors: | J Campos S García-Tornel J M Gairí I Fábregues |
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| Institution: | 1. Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA;2. Department of Chemistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA;3. Center of Excellence in NanoBiophysics, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA;1. Sección Virología, Facultad de Ciencias, Universidad de la República, Iguá 4225, 11400 Montevideo, Uruguay;2. Servicio de Hepatología, Hospital Central de las Fuerzas Armadas, Ministerio de Defensa Nacional, Avenida 8 de Octubre 3060, 11800 Montevideo, Uruguay |
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| Abstract: | Thirty-five patients with meningitis caused by Haemophilus influenzae type b were admitted to our hospital from January 1981 to December 1984; 60% of the strains were resistant to ampicillin, 65.7% to chloramphenicol, and 57% to both antibiotics. No significant differences in age, sex, previous treatment, clinical symptoms, outcome, and mortality were found between the 20 patients whose strains were resistant to both ampicillin and chloramphenicol and the other 15 patients whose strains were susceptible to ampicillin, chloramphenicol, or both. Alternative therapeutic agents were a combination of carbenicillin and gentamicin and new cephalosporins. At present, cefotaxime is our treatment of choice for meningitis caused by H. influenzae type b. |
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