Open-heart surgery in Jehovah's Witness patients |
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| Affiliation: | 1. Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea;2. Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea;3. Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea;4. Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Republic of Korea;5. Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Republic of Korea;1. Department of Radiology, Cardiac MR/CT Unit, Rouen University Hospital, 1, rue de Germont, 76031 Rouen cedex, France;2. Inserm U1096, Normandie University UNIROUEN, 22, boulevard Gambetta, 76000 Rouen, France;3. Department of Cardiology, Rouen University Hospital, 1, rue de Germont, 76031 Rouen cedex, France;1. Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China;2. Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, China;3. Aortic Institute at Yale-New Haven, Yale School of Medicine, New Haven, Conn;4. Department of Chronic Disease Epidemiology, Yale School of Public Health and Center for Biomedical Data Science, Yale School of Medicine, New Haven, Conn;1. Department of Internal Medicine, Bridgeport Hospital, Yale-New Haven Health System, Bridgeport, CT, 06610, USA;2. Department of Infectious Diseases, Bridgeport Hospital, Yale-New Haven Health System, Bridgeport, CT, 06610, USA |
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| Abstract: | Open-heart surgery has been performed since 1975 on 25 patients who are Jehovah's Witnesses by religion. The patients' ages ranged from 6–60 years, and their body weights from 18–51 kg. Surgical procedures included correction of congenital heart disease in 14 patients and valve repair or replacement in 11. Six procedures were reoperations. The lowest mean haematocrits, during perfusion and the postoperative period, were 22.7% (range 15.0–31.0%) and 27% (range 16.0–36.0%), respectively. Twenty-four patients survived and are alive and well. One patient died of low output failure before discharge. The blood return system reduced blood loss. Five of the patients who underwent cardiac surgery received recombinant erythropoietin before and after surgery, leading to higher postoperative haematocrits. In one patient, a haematocrit which fell to 16.9% after surgery was raised to 27% by administration of erythropoietin, without blood transfusion. In two recent cases, high doses of aprotinin were used during surgery, resulting in better haemostasis after cardiopulmonary bypass. |
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