Investigation of chromosome 9q22.3-q31 DNA marker loss in odontogenic keratocysts |
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| Institution: | 1. Division of Dental Surgery, Leeds Dental Institute, Leeds LS2 9LU U.K.;2. Molecular Medicine Unit, St. James''s University Hospital, Leeds LS9 7TF, U.K.;1. School of Dentistry, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile;2. Institute of Pharmacy, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile;3. Faculty of Dentistry, Universidad San Sebastián, Santiago, Chile;4. Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil;5. School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, RM, Chile;6. Pharmacology and Toxicology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, RM, Chile;1. Instituto de Ciencia de Materiales de Madrid, CSIC, c/ Sor Juana Inés de la Cruz, 3, Cantoblanco, 28049 Madrid, Spain;2. Instituto de Ciencia de Materiales de Sevilla, Centro Mixto Universidad de Sevilla-CSIC, c/Américo Vespucio, 49, 41092 Sevilla, Spain;1. Universidad Icesi, Joven Investigador Colciencias 2013-2014. Facultad de Ciencias de la Salud, Cali, Colombia;2. Universidad Icesi. Docente tiempo completo. Facultad de Ciencias de la Salud, Cali, Colombia;3. Hospital Fundación Valle del Lili. Unidad de Cuidados Intensivos Adultos, Cali, Colombia;1. Zoology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt;2. Biology Department, Faculty of Science, Taif University, Taif 888, Saudi Arabia;3. Zoology Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt |
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| Abstract: | Multiple basal cell carcinomas and odontogenic keratocysts of the jaws are a feature of the inherited naevoid basal cell carcinoma syndrome (NBCCS), although both occur more commonly as single, sporadic cases. The NBCCS gene has been mapped to chromosome 9q22.3-q31 and loss of heterozygosity for DNA markers from this region has been observed in familial and sporadic basal cell carcinomas. Based on these observations, we undertook a pilot study to determine if a similar pattern of chromosome loss occurs in odontogenic keratocysts. DNA extracted from microdissected odontogenic keratocyst epithelium was examined for loss of heterozygosity for six polymorphic DNA markers mapping to human chromosome 9q22.3-q31. Allelotype loss was detected in epithelium from three, single, sporadic odontogenic keratocysts. These results implicate homozygous inactivation of the NBCCS gene in the initiation and progression of the odontogenic keratocyst. |
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