| 血管内皮生长因子在乳腺癌中的表达及意义 |
| |
| 引用本文： | 翁海滨,李森,任家胜.血管内皮生长因子在乳腺癌中的表达及意义[J].现代医药卫生,2008,24(4):488-489. |
| |
| 作者姓名： | 翁海滨 李森 任家胜 |
| |
| 作者单位： | 聊城市人民医院,山东,聊城,252000 |
| |
| 摘 要： | 目的：探讨血管内皮生长因子（VEGF）在乳腺癌中的表达及其临床意义。方法：应用免疫组织化学法检测74例乳腺癌组织中VEGF的表达。分析其与乳腺癌临床病理特征及预后的关系。结果：VEGF的阳性表达率为64．9％。VEGF的表达与肿瘤大小（P〈0．05）、临床分期（P〈0．05）、腋淋巴结转移（P〈0．05）有关。VEGF表达阴性和阳性两组5年总生存率（overall survival，OS）和无瘤生存率（disease free survival，DFS）差异有显著性（P〈0．05）。结论：VEGF阳性表达提示乳腺癌预后不良。VEGF可为判断乳腺癌预后的有效指标。
|
| 关 键 词： | 乳腺癌 血管内皮生长因子 预后 |
| 文章编号： | 1009-5519（2008）04-0488-02 |
| 收稿时间： | 2007-10-15 |
| 修稿时间： | 2007年10月15 |
Significance of vascular endothelial growth factor expression in breast carcinoma |
| |
| WENG Hai-bin,LI Sen,REN Jia-sheng.Significance of vascular endothelial growth factor expression in breast carcinoma[J].Modern Medicine Health,2008,24(4):488-489. |
| |
| Authors: | WENG Hai-bin LI Sen REN Jia-sheng |
| |
| Abstract: | Objective:To investigate the expression of vascular endothelial growth factor (VEGF) in breast carcinoma and the clinical significance. Methods:74 women with primary breast carcinoma were studied for the expression of VEGF using immunohistochemical assay.The association of VEGF expression with clinical pathological characteristics and prognosis was further analyzed.Results:64.9% breast cancer cases were found with positive expression for VEGF.The expression of VEGF were related to tumor size(P<0.05),clinical stage(P<0.05) and lymph node metastasis(P<0.05).Both overall survival (OS) and disease free survival (DFS) were statistically significant between VEGF expression negative and VEGF expression positive respectively. Conclusion:VEGF expression may be a poor prognosis for human breast cancer.VEGF is an important prognostic factor in breast cancer. |
| |
| Keywords: | Breast cancer Vascular endothelial growth factors Prognosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
