老年非溃疡性消化不良患者胃液体排空与血浆胃动素、生长抑素关系的研究

采用实时超声显像法与放射免疫法,对20例老年NUD患者及15例对照者进行胃液体排空时间的测定及血浆胃动素、生长抑素的检测,探讨老年NUD患者目排空运动与胃肠激素之间的关系.结果显示:老年NUD患者胃液体排空T1/2为39.00±11.65min,较对照组的29.33±7.99min明显延迟(P<0.01).老年NUD患者胃动素浓度为471.5±63.06pg/ml,生长抑素浓度为63.83±11.88pg/ml,较对照组分别下降和升高(P均<0.01).老年NUD患者胃液体排空T1/2与胃动素浓度呈负相关(r=-0.936,P<0.01),与生长抑素浓度呈正相关(r=0.942,P<0.01).表明老年NUD患者胃液体排空障碍与胃动素分泌下降及生长抑素分泌增高相关.

A Study on the Relationship Between Gastric Emptying of Liquids and Plasma Motilin, Somatostatin Concentrations in Elderly Patients with Non Ulcer Dyspepsia

In order to clarify the relationship between gastric emptying of liquids and gut hormones, the gastric half-emptying time of liquids and the plasma motilin, somato-statin concentrations were studied in 20 elderly patients with non ulcer dyspepsia (NUD) and 15 normal controls. The results showed that: gastric half-emptying time of liquids was delayed in elderly patients with NUD as compared to that of controls ( P < 0. 01); the plasma motilin concentration reduced and the somatostatin concentration increased significantly as compared with that of controls (P<0.01); there was an excellent correlation between the gastric half-emptying time and motilin concentration (r=-0.936) and somatostatin concentration (r=0. 942) in elderly patients with NUD. The present study suggested that dysfunction of gastric motility be associated with the reduction of motilin secretion and the increasing of somatostatin secretion.