| 力生长因子的表达及其在组织修复与再生中的作用 |
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| 引用本文： | Zhang B,Song G,Luo Q,Yang L. 力生长因子的表达及其在组织修复与再生中的作用[J]. 中国修复重建外科杂志, 2012, 26(5): 617-620 |
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| 作者姓名： | Zhang B Song G Luo Q Yang L |
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| 作者单位： | 重庆大学生物工程学院 |
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| 基金项目： | 国家自然科学基金资助项目(11032012);中央高校基本科研业务费科研专项自然科学类资助项目(CDJXS11230025)~~ |
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| 摘 要： | 目的对力生长因子(mechano-growth factor,MGF)的表达以及在组织修复与再生中的作用进行综述。方法广泛查阅近年来国内外有关MGF表达和参与组织修复与再生的文献,对其研究进展进行综述。结果 MGF在多种组织/细胞中表达,具有力敏感性,并能激活卫星细胞,促进成肌细胞增殖,在治疗肌肉缺损、预防心肌损伤和修复受损神经等方面起重要作用。结论 MGF在多种组织中的修复作用已明确,但其具体作用机制尚未明确,有待进一步深入研究。
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| 关 键 词： | 力生长因子 IGF-Ⅰ 组织修复 组织再生 |
Expression of mechano-growth factor and its roles in tissue repairs and regeneration |
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| Zhang Bingyu,Song Guanbin,Luo Qing,Yang Li. Expression of mechano-growth factor and its roles in tissue repairs and regeneration[J]. Chinese journal of reparative and reconstructive surgery, 2012, 26(5): 617-620 |
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| Authors: | Zhang Bingyu Song Guanbin Luo Qing Yang Li |
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| Affiliation: | College of Bioengineering, Chongqing University, Chongqing 400044, PR China. |
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| Abstract: | Objective To review the expression of mechano-growth factor(MGF) and its roles in tissue repairs and regeneration. Methods The literature about the expression of MGF and its roles in tissue repairs and regeneration in recent years was reviewed. Results MGF is sensitive to mechanical stimulation and can be expressed in various tissues/cells.MGF is responsible for satellite cell activation,myoblast proliferation,and plays important roles in the treatment of muscle coloboma,prevention of myocardial injury,and neuroprotection.Conclusion The important role of MGF in tissue repairs and regeneration has been identified,however,the detailed mechanisms remain unclear up to now and still need a further study. |
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| Keywords: | Mechano-growth factor Insulin-like growth factor I Tissue repair Tissue regeneration |
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