The diagnostic and prognostic value of 18F-FDG PET/CT in the initial assessment of high-grade bone and soft tissue sarcoma. A retrospective study of 89 patients |
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Authors: | Hanna Maria Fugl? Simon M?ller J?rgensen Annika Loft Dorrit Hovgaard Michael M Petersen |
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Institution: | Department of Orthopaedic Surgery, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen ?, Denmark. |
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Abstract: | Purpose To evaluate the feasibility of 18F-FDG PET/CT for initial assessment in high-grade bone sarcomas (BS) and soft tissue sarcomas (STS). Methods During the years 2001–2010, 89 patients (30 BS, 59 STS) referred for further evaluation and surgical treatment of a high-grade BS or STS also had a PET/CT scan performed for staging preoperatively (n?=?68) or within 1?month of surgery (n?=?21). Metastatic lesions suggested on the PET/CT scan were confirmed or rejected by histological evaluation, by additional imaging or by follow-up. In 68 patients (28 BS, 40 STS) the relationship between the maximal standardized uptake value (SUVmax) of the primary tumour and survival was examined. Results The PET/CT scan suggested the presence of 13 metastatic lesions in BS patients (5 lymph node, 8 distant) and 21 metastatic lesions (6 lymph node, 15 distant) in STS patients. The calculated sensitivity (SE) and specificity (SP) were 95?% and 96?% for detection of distant metastases, and the predictive value (PV) of a positive or a negative test was 87?% and 98?%, respectively. SE and SP were 100?% and 90?% for detection of lymph node metastases, and the PV of a positive or a negative test was 27?% and 100?%, respectively. The 5-year survival was 81?% among patients with SUVmax below the median value (≤10), but was 33?% among those with SUVmax >10. Conclusion FDG PET/CT for the initial assessment of patients with high-grade BS or STS was feasible with high SE and SP, but in those with lymph node metastases the PV of a positive test was low. The SUVmax of the primary tumour was a strong prognostic factor for survival. |
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