Hep-1表达对评价肝细胞癌手术切除预后的价值

目的:研究Hep-1与原发性肝细胞癌术后无瘤生存的相关性,探讨其预测手术疗效的价值。方法:对279例行手术切除并经病理证实的原发性肝细胞癌患者进行回顾性随访,将完整的随访资料同临床和病理特征进行单因素和多因素分析,单因素分析采用Kaplan-Meier法计算,Cox回归进行多因素分析。结果:单因素分析结果显示,年龄、肿瘤大小、门静脉癌栓、肿瘤包膜、子灶、微血管侵犯、Hep-1水平、pCEA水平、CD34水平、术前AFP值、BCLC分级等11个相关临床病理因素影响HCC术后无瘤生存时间;多因素分析显示,肿瘤有无包膜、门静脉癌栓、术前AFP值、有无子灶和术后Hep-1水平与无瘤生存期有着密切关系。结论:肝细胞癌患者术后病理免疫组织化学指标Hep-1能较客观地预测术后肿瘤复发情况,有助于临床医师治疗方法的选择。

Significance of Hep-1 in prognostic hepatocelluar carcinoma following surgical resection

Objective： To investigate correlation between Hep-1 of HCC and disease-free survival time（DFS） after hepatectomy. Methods： A retrospective survey was carried out in 238 cases with hepatocellular carcinoma （HCC） receiving surgical resection. The factors under consider- ation were analysed using Cox proportional Hazards survival model and Kaplan-Meier estimation.isul： Univariate analysis showed that 11 clinical and pathologic factors, including size of tumor, growing pattern, portalve in tumor thrombus, encapsulation of tumor, daughter nodules （including microscopic nodules）, microvessel invasion, Hep-1, AFP level before hepatectomy and so on, might all influence canoer-free survival time. Multivariate analysis revealed five significant prognostic fac- tors：portalve in tumor thrombus, encapsulation of tumor, daughter nodules （including microscopic nodules）, Hep-1, AFP level before hepatectomy. These five factors were encompassed. Conclusion Hep-1 is one of the most significant prognostic factors determining tumor-free survival after HCC resection.