| 放射基因组学在精准放疗中的研究进展 |
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| 引用本文： | 叶菲,余盈. 放射基因组学在精准放疗中的研究进展[J]. 基础医学与临床, 2020, 40(5): 696-700. DOI: 10.3969/j.issn.1001-6325.2020.05.023 |
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| 作者姓名： | 叶菲 余盈 |
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| 作者单位： | 华中科技大学 同济医学院附属协和医院 普外科,湖北 武汉430022;华中科技大学 同济医学院附属协和医院 普外科,湖北 武汉430022 |
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| 摘 要： | 在精准医疗的背景下,放射基因组学作为一种将放射组学与基因组学结合在一起进行多组学研究的新型策略,在预测基因组结构及表达的改变、构建放射生物学的物理模型上等方面具有独到的优势。尤其是在精准放疗方面,囊括影像-基因两个维度的具有放射基因组学特点的模型可以提供多组学的信息,进而精准地指导临床决策,在提高患者生存率的同时,减少放疗带来的并发症。
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| 关 键 词： | 放射基因组学 机器学习 精准放疗 个体化医疗 |
Advances in radiogenomics in precision radiotherapy |
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| YE Fei,YU Ying. Advances in radiogenomics in precision radiotherapy[J]. Basic Medical Sciences and Clinics, 2020, 40(5): 696-700. DOI: 10.3969/j.issn.1001-6325.2020.05.023 |
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| Authors: | YE Fei YU Ying |
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| Affiliation: | (Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China) |
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| Abstract: | In the background of precision medicine,radiogenomics is a new strategy that combines radiomics and genomics for multi-omics research.It has unique advantages in predicting changes of genome expression and structure and establishing the physics model of radiobiology.Especially in terms of precision radiotherapy,a model of radiation genomics that encompasses the two dimensions of images-gene can provide multi-omics information and accurately guide clinical therapy,which increases the rate of patient survival and reduces the radiotherapy band coming complications. |
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| Keywords: | radiogenomics machine learning precision radiotherapy individualized medicine |
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