| 血管紧张素转换酶2与心血管疾病研究进展 |
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| 引用本文： | 焦晓璐,秦彦文. 血管紧张素转换酶2与心血管疾病研究进展[J]. 基础医学与临床, 2020, 40(5): 701-706. DOI: 10.3969/j.issn.1001-6325.2020.05.024 |
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| 作者姓名： | 焦晓璐 秦彦文 |
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| 作者单位： | 首都医科大学附属北京安贞医院 北京市心肺血管疾病研究所 上气道功能障碍相关心血管疾病北京市重点实验室,北京100029;首都医科大学附属北京安贞医院 北京市心肺血管疾病研究所 上气道功能障碍相关心血管疾病北京市重点实验室,北京100029 |
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| 基金项目： | 北京市自然科学基金;国家自然科学基金 |
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| 摘 要： | 血管紧张素转换酶2(ACE2)是SARS病毒(SARS-CoV)、新型冠状病毒(SARS-CoV-2)感染机体的主要受体,也是肾素-血管紧张素-醛固酮系统的主要成员之一。ACE2对多种心血管疾病具有保护作用,SARS-CoV-2可以降低机体ACE2的表达,这可能是新型冠状病毒肺炎(COVID-19)后期产生心血管并发症的原因之一。本文总结了ACE2在多种心血管疾病发病过程中的作用及其机制,希望为新型冠状病毒肺炎(COVID-19)的治疗提供新的思路。
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| 关 键 词： | 血管紧张素转换酶2 心血管疾病 肾素-血管紧张素-醛固酮系统 |
Progress of angiotensin converting enzyme 2 in cardiovascular diseases |
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| JIAO Xiao-lu,QIN Yan-wen. Progress of angiotensin converting enzyme 2 in cardiovascular diseases[J]. Basic Medical Sciences and Clinics, 2020, 40(5): 701-706. DOI: 10.3969/j.issn.1001-6325.2020.05.024 |
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| Authors: | JIAO Xiao-lu QIN Yan-wen |
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| Affiliation: | (the Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China) |
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| Abstract: | Angiotensin-converting enzyme 2(ACE2)is the receptor for SARS-CoV and SARS-CoV-2(severe acute respiratory syndrom coronavirus 2)viruses,and it is also one of the main family members of renin-angiotensin-aldosterone system.ACE2 has a protective effect on cardiovascular diseases and inhibits the development of cardiovascular diseases.SARS-CoV-2 reduces the expression of ACE2 of host,which may be one of the reasons for cardiovascular complications in the later stage of coronavirus disease 2019(COVID-19).Thus,the role and mechanism of ACE2 in the development of cardiovascular diseases were summarized in this article in order to provide potential stratigy development for the treatment of COVID-19. |
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| Keywords: | angiotensin-converting enzyme 2 cardiovascular diseases renin-angiotensin-aldosterone system |
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