Outcome of severe acute post-streptococcal glomerulonephritis in New Zealand children |
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Authors: | William Wong Maxwell Clarke Morris Jonathan Zwi |
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Institution: | (1) Department of Nephrology, Starship Children’s Hospital, Private Bag 92024, Auckland, New Zealand;(2) Department of Anatomic Pathology, LabPLus, Auckland City Hospital, Auckland, New Zealand |
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Abstract: | Post-streptococcal glomerulonephritis (PSGN) is the commonest cause of severe acute glomerulonephritis in New Zealand children,
with the majority (85%) of the patients being of either Pacific Island or Maori ethnicity. We have performed a retrospective
study on 27 pediatric patients with acute PSGN. Of these patients, those with crescentic glomerulonephritis (n = 11) had a greater tendency (72.7%) for needing acute dialysis and were left with persistent urinary sediment abnormalities
after a mean follow-up of 3.2 years (95% confidence interval 2.1–4.3). The efficacy of immunosuppression in the group with
crescentic disease was uncertain. The severity of renal histopathological abnormalities as judged by the total biopsy score
did not correlate with either presentation or eventual outcome. Severe childhood acute post-streptococcal glomerulonephritis,
although uncommon, results in significant long-term renal morbidity, particularly among Maori and Pacific Island children. |
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Keywords: | Acute glomerulonephritis Crescentic Infection Post-streptococcal Rapidly progressive children |
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