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环氧化酶-2 在膀胱癌组织及尿脱落细胞中的表达和意义
引用本文:崔书平,霍红旭,黑兰荪,常学良.环氧化酶-2 在膀胱癌组织及尿脱落细胞中的表达和意义[J].肿瘤防治研究,2005,32(5):299-301.
作者姓名:崔书平  霍红旭  黑兰荪  常学良
作者单位:1. 050040,石家庄,解放军260医院泌尿外科
2. 河北医科大学第二附属医院泌尿外科
摘    要: 目的 探讨COX-2在膀胱癌组织中的表达,了解尿脱落细胞COX-2表达在膀胱癌早期诊断中的价值。方法 应用免疫组化技术检测48例膀胱移行细胞癌组织、免疫细胞化学技术检测40例膀胱移行细胞癌患者和30例非肿瘤患者尿脱落细胞COX-2的表达。结果 膀胱移行细胞癌组织COX-2阳性表达率为72.9%,对照组正常膀胱黏膜无表达。COX-2的表达与膀胱癌临床分期显著相关(P<0.05),不同病理分级膀胱癌的表达差别无显著性意义。非肿瘤患者尿脱落细胞无COx-2表达,膀胱癌尿脱落细胞COX-2免疫细胞化学检测阳性率为67.5%,明显高于常规尿细胞学的37.5%(P<0.05),尤其对于G1级和Ta~T1期的低级、早期肿瘤,尿脱落细胞COX-2免疫细胞化学检测与常规尿细胞学检查相比,具有显著性意义(P<0.05)。结论 COX-2在膀胱移行细胞癌的发生发展中起重要作用,与肿瘤的浸润、转移相关。尿脱落细胞COX-2表达检测特异性高,可作为早期诊断膀胱癌的一种标志物。

关 键 词:膀胱肿瘤  移行细胞癌  环氧化酶-2  尿细胞学
文章编号:1000-8578(2005)05-0299-03
收稿时间:2004-4-28
修稿时间:2004-8-3

Expression of Cyclooxygenase-2 in Human Transitional Cell Carcinoma of the Urinary Bladder and Exfoliated Urothelial Cells of Bladder Cancer
CUI Shu-ping,HUO Hong-xu,HEI Lan-sun,CHANG Xue-liang.Expression of Cyclooxygenase-2 in Human Transitional Cell Carcinoma of the Urinary Bladder and Exfoliated Urothelial Cells of Bladder Cancer[J].Cancer Research on Prevention and Treatment,2005,32(5):299-301.
Authors:CUI Shu-ping  HUO Hong-xu  HEI Lan-sun  CHANG Xue-liang
Institution:1. Department of Urology , PLA No. 260 Hospital , Shijiazhuang 050040 , China; 2. Department of Urology , Second Affiliated Hospital , Hebei Medical University
Abstract:Objective  To investigate the significance of expression of cyclooxygenase-2 (COX-2) in human transitional cell carcinomas ( TCCs) of the urinary bladder and to evaluate the value of COX-2 expression in exfoliated urothelial cells in early diagnosis. Methods  The expression of COX-2 in human TCCs of the urinary bladder was observed with immunohistochemical methods and COX-2 immunocytology were performed on exfoliated urothelial cells in the patient s with TCC and 30 subject s with normal urothelium. Results  COX-2 specific proteins were found in 35 of 48 TCC specimens but not in cont rol urinary bladder tissues. There are statistical significances between the Ta-1>> and T224>> stage cases ( P < 0. 05) , but no correlation was found between COX-2 and tumor grading. The expression of COX-2 was negative in all controls. The positive staining of COX-2 in exfoliated urothelial cells of patient s with TCC was 67. 5 % , which was significantly higher than the positive rate of cytopathology (37. 5 %) ( P < 0. 05) , especially in low grade ( G1 ) and low stage ( Ta~T1) cancer. Conclusions  The result s suggested that COX-2 overexpression plays a role in development and invasion of TCCs. COX-2 immunocytology had a higher specificity in detection of bladder tumors and therefore would be a good marker in early diagnosis.
Keywords:Bladder neoplasms  Cyclooxygenase-2  Transitional cell carcinomas  Urinary cytology
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