| 消疲怡神口服液对应激大鼠下丘脑—垂体—肾上腺—胸腺轴？… |
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| 引用本文： | 王琳 王天芳. 消疲怡神口服液对应激大鼠下丘脑—垂体—肾上腺—胸腺轴？…[J]. 中国中西医结合杂志, 2000, 20(2): 116-119 |
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| 作者姓名： | 王琳 王天芳 |
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| 作者单位： | 北京医药大学中医诊断学教研室 |
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| 基金项目： | 国家自然科学基金!No .3950 0 1 84，国家中医药管理局!No.95B1 0 9 |
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| 摘 要： | 目的：探讨消疲怡神口服液抗应激的作用机理。方法：观察了消疲怡神口服液对强制冷水游泳大鼠模型血清单胺类物质、肾上腺抗坏血酸和下丘脑垂体单胺类递质含量及胸腺指数的影响。结果：消疲怡神口服液可以拮抗应激所致血清多巴胺、５－羟色胺含量升高和肾上腺抗坏血酸含量降低，使降低的下丘脑垂体去甲肾上腺素、５－羟色胺含量回升，但对胸腺旨数无明显影响。结论：消疲怡神口服液的作用机制与其对机体下丘脑－垂体－肾上腺－胸腺轴
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| 关 键 词： | 消疲怡神口服液 下丘脑 垂体 肾上腺 胸腺轴 应 |
Effectsof Xiaopi Yishen Oral Liquid on Hypothalamus-Pituitary-Adrenal Gland-Thymus Axis inStressed Rats |
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| WANG Lin,WANG Tianfang,KANG Chunjie,et al Beijing University of Traditional Chinese Medicine,Beijing. Effectsof Xiaopi Yishen Oral Liquid on Hypothalamus-Pituitary-Adrenal Gland-Thymus Axis inStressed Rats[J]. Chinese journal of integrated traditional and Western medicine, 2000, 20(2): 116-119 |
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| Authors: | WANG Lin WANG Tianfang KANG Chunjie et al Beijing University of Traditional Chinese Medicine Beijing |
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| Affiliation: | Beijing University of Traditional Chinese Medicine, Beijing (100029). |
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| Abstract: | To investigate the effect of Xiaopi Yishen (XPYS) oral liquid on the rats under repeated forced cold water swimming (RFCWS) stress. Methods: The changes of serum monoamine, ascorbic acid levels in adrenal gland, monoamine levels in hypothalamus and hypophysis, and thymus index were determined. Results: XPYS lowered the increasing of serum DA, 5 HT, improved the reducing of ascorbic acid in adrenal gland and NE, HVA, 5 HT, 5 HITT in hypothalamus and hypophysis of RFCWS stressed rats. Conclusion: The mechanism of XPYS is in connection with the regulation of hypothalamus pituitary adrenal gland thymus axis. |
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| Keywords: | Xiaopi Yishen oral liquid repeated forced cold water swimming hypothalamus pituitary adrenal gland thymus axis |
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