| 从形态学角度观察鼻敏片对豚鼠变应性鼻炎的影响 |
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| 引用本文： | 文志,徐绍勤,周光源,李凡成,彭斌.从形态学角度观察鼻敏片对豚鼠变应性鼻炎的影响[J].中药新药与临床药理,2004,15(5):312-314. |
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| 作者姓名： | 文志 徐绍勤 周光源 李凡成 彭斌 |
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| 作者单位： | 1. 湖南中医学院附属二医院耳鼻喉科,长沙,410005
2. 湖南中医学院成教学院,长沙,410007 |
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| 摘 要： | 目的观察鼻敏片对豚鼠变应性鼻炎鼻黏膜形态学的影响,探讨其治疗机制.方法以甲苯 2, 4-二异氰酸酯为致敏原,对豚鼠行鼻内给药法建立鼻超敏反应模型,以息斯敏为对照药,对鼻粘膜形态学进行观察.结果 鼻敏片能减轻鼻部流涕、喷嚏等症状,抑制炎症细胞的聚集,促进鼻黏膜修复,药效较息斯敏持久.结论鼻敏片能有效治疗变应性鼻炎.
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| 关 键 词： | 鼻敏片 变应性鼻炎 鼻粘膜形态学 |
| 文章编号： | 1003-9783(2004)05-0312-03 |
| 修稿时间： | 2004年3月10日 |
Effect of Bimin Tablet on Morphological Changes of the Nasal Mucosa of Guinea Pigs with Allergic Rhinitis |
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| WEN Zhi,XU Shaoqin,ZHOU Guangyuan,LI Fancheng,PENG Bin.Effect of Bimin Tablet on Morphological Changes of the Nasal Mucosa of Guinea Pigs with Allergic Rhinitis[J].Traditional Chinese Drug Research & Clinical Pharmacology,2004,15(5):312-314. |
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| Authors: | WEN Zhi XU Shaoqin ZHOU Guangyuan LI Fancheng PENG Bin |
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| Institution: | WEN Zhi1,XU Shaoqin1,ZHOU Guangyuan1,LI Fancheng2,PENG Bin1 |
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| Abstract: | Objective To investigate the effect of Bimin tablet on morphological changes of the nasal mucosa of guinea pigs with allergic rhinitis. Methods Toluene 2,4-diisocyanate (TDI) was used intranasally as allergen to induce guinea pigs models with hypersensitivity and Xisimin was used as the positive control. The morphological changes of the nasal mucosa in guinea pigs were observed. Results Bimin tablet could reduce the symptoms such as nasal discharge and sneezing, inhibit inflammatory cell infiltration and promote the restoration of the nasal mucosa. The effect of Bimin tablet lasted a longer time than that of Xisimin. Conclusion Bimin tablet is effective in treating allergic rhinitis. |
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| Keywords: | Bimin tablet Allergic rhinitis Morphology nasal mucosa |
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