Etoposide in prostatic cancer: experimental studies and phase II trial in patients with bidimensionally measurable disease |
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| Authors: | Howard I Scher Cora Sternberg Warren D W Heston Robin C Watson Donna Niedzwiecki Tracy Smart Phyllis Hollander Alan Yagoda the Community Cancer Oncology Program Investigators |
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| Institution: | (1) Solid Tumor Serivce, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021 New York, NY;(2) Urologic Oncology Research Laboratory, Division of Urology, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021 New York, NY;(3) Department of Medical Imaging, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021 New York, NY;(4) Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021 New York, NY;(5) Department of Medicine, Cornell University Medical College, New York, NY, USA |
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| Abstract: | Summary Etoposide, a semisynthetic derivative of podophyllotoxin, was evaluated concurrently in vitro against a human derived hormone-resistant cell line, PC-3, and in vivo in bidimensionally measurable hormone-resistant human prostatic cancer. In vitro, a dose-response relationship was observed, with 74% inhibition at 10  g/ml (1 h incubation) and >99% inhibition at 90 g/ml, both in the range of clinically achievable concentrations. In vivo, 1 PR (5%, 95% confidence limits 0–12%) of 18+ months was observed in 20 adequately treated patients. The results confirm the limited role of etoposide in hormone-refractory disease and the need for new model systems for evaluation of potential chemotherapeutic compounds in this disease.Supported in part by Public Health Service Grants CA-05826, CA-39203 and CA-90207 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, and the David H. Cogan Fund for Prostate Cancer ResearchRecipient of an American Cancer Society Clinical Oncology Career Development Award |
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