Category fluency is also predominantly affected in Swiss Alzheimer's disease patients |
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| Authors: | A. U. Monsch,E. Seifritz,K. I. Taylor,D. Ermini-Fü nfschilling,H. B. Stä helin,R. Spiegel |
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| Affiliation: | Memory Clinic, Geriatric University Clinic, Basel, Switzerland;Department of Veterans Affairs Medical Center and Department of Psychiatry, School of Medicine, University of California, San Diego, USA;University of Zürich, Switzerland;DRRA Strategy CNS Group, Sandoz Pharma AG, Basel, Switzerland |
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| Abstract: | Objectives – To establish the comparative efficacy to differentiate between Swiss patients with dementia of the Alzheimer type (DAT) and elderly normal control subjects (NC) on two different verbal fluency tasks: category fluency and letter fluency. Material and methods – Fifty Swiss German DAT patients in the early stages of the disease and 50 matched normal control subjects were compared on letter and category fluency tasks. Results – DAT patients exhibited an overproportional impairment on category fluency as compared with letter fluency. Receiver operating characteristic curves (ROC) showed that category fluency correctly classified a significantly higher number of DAT patients and NC subjects (84%) than letter fluency (70%). Conclusion – As similar findings have been described for English-speaking DAT patients, we conclude that deficiencies in category fluency are a general phenomenon, reflecting impaired structures of semantic knowledge occurring early in the course of Alzheimer's disease. |
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| Keywords: | verbal fluency category fluency letter fluency Alzheimer's disease receiver operating characteristic curve |
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