| rhG—CSF增加实验性脑缺血周围区的nestin蛋白表达 |
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| 引用本文： | 于炳新,吕传真,罗玉敏. rhG—CSF增加实验性脑缺血周围区的nestin蛋白表达[J]. 中国临床神经科学, 2003, 11(2): 150-152 |
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| 作者姓名： | 于炳新 吕传真 罗玉敏 |
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| 作者单位： | 复旦大学附属华山医院神经科,200040 |
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| 摘 要： | 目的研究重组人粒细胞集落刺激因子(recombinant human granulocyte colony-stimulatingfactor,rhG-CSF)对大鼠局灶性脑缺血的神经元保护作用.方法用线栓法建立大鼠大脑中动脉缺血再灌注模型,于再灌注不同时间点对治疗组和对照组进行神经缺损评分(NSS);并用免疫组织化学方法测定神经上皮干细胞蛋白(nestin)的表达.结果与对照组相比,rhG-CSF治疗组大鼠的神经缺损评分明显降低(P＜0.05);治疗组脑梗死区周围的nestin表达较对照组增多.结论脑缺血再灌注后,一定剂量rhG-CSF可能通过提高nestin的表达,增加神经细胞的修复,改善脑卒中的预后.
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| 关 键 词： | 重组人粒细胞集落刺激因子 脑缺血 神经上皮干细胞蛋白 |
| 文章编号： | 1008-0678(2003)02-0150-03 |
| 修稿时间： | 2003-04-03 |
rhG-CSF Enhances Nestin Protein Expression in Boundary Zone of the Ischemic Lesion in MCAO Models |
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| YU Bing-Xin,LU Chuang-Zhen,LUO Yu-Min. rhG-CSF Enhances Nestin Protein Expression in Boundary Zone of the Ischemic Lesion in MCAO Models[J]. Chinese Journal of Clinical Neurosciences, 2003, 11(2): 150-152 |
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| Authors: | YU Bing-Xin LU Chuang-Zhen LUO Yu-Min |
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| Affiliation: | YU Bing-Xin,LU Chuang-Zhen,LUO Yu-Min. Department of Neurology,Huashan Hospital,Fudan University,Shanghai 200040,China |
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| Abstract: | Aim: To test the protective effects of rhgG-CSF on the neurons after focal cerebral ischemia in rats. Methods: A model of focal brain ischemia/reperfusion in rats, was performed with the intraluminal filament occlusion. The effects of rhG-CSF were evaluated by neurological severity score, and using immunohistochemistry to study the expression of nestin protein. Results: rhG-CSF significantly reduced the neurological severity scores, and increased the expression of nestin in peri-infarcted zones after reperfusion of focal ischemia. Conclusion: The rhG-CSF treatment may enhance the repairement by increasing the nestin expression, thus improve functional outcome of stroke. |
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| Keywords: | recombinant human granulocyte colony stimulating factor (rhG-CSF) cerebral ischemia neuroepithelial stem protein (nestin) |
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