依巴斯汀治疗慢性特发性荨麻疹的疗效及安全性

目的：观察依巴斯汀治疗慢性特发性荨麻疹患者的疗效及安全性。方法：对68例慢性特发性荨麻疹患者应用依巴斯汀10mg，qd，连续治疗4周，干治疗后2，4和8周时复诊观察记录疗效及不良反应。结果：用药2周时痊愈32例（47．1％），显效41例（显效率60．3％）；4周时痊愈38例（55．9％），显效46例（显效率67．6％）：8周时痊愈41例（60．3％），显效48例（显效率70．1％）。2周时3例出现轻度头晕（4．4％），4周复诊时消失．8周时无明显不良反应。结论：依巴斯汀治疗慢性特发性荨麻疹安全有效。

Efficacy and safety of ebastine on chronic idiopathic urticaria

Objective:To evaluate the efficacy and safety of ebastine in the treatment of chronic idiopathic urticaria.Methods:68 patients with chronic idiopathic urticaria were randomized to orally re- ceive ebastine 10 mg qd for 4 weeks.The patients were followed up at the end of 2,4 and 8 weeks after the treatment.Results:In the 2-week therapy,the cure rate was 47.1% (32/68) and effectual rate 60.3% (41/68);in the 4-week therapy,the cure rate was 55.9% (38/6) and effectual rate 67.6% (46/68);in the 8-week therapy,the cure rate was 60.3% (41/68) and effectual rate 70.1% (48/ 68).Three patients complained slight headache in 2 weeks after the treatment.However,the headache vanished when the patients continued the treatment.No serious adverse events were reported.Conclu- tion:Ebastine offers a therapeutic option in the treatment of chronic idiopathic urticaria.