The gp120 glycoprotein of HIV-1 binds to sulfatide and to the myelin associated glycoprotein. |
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| Authors: | L H van den Berg S A Sadiq S Lederman N Latov |
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| Affiliation: | Department of Neurology, Columbia University, New York NY 10032. |
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| Abstract: | We investigated the binding of the gp120 glycoprotein of the human immunodeficiency virus (HIV-1) to neural glycolipids and glycoproteins by ELISA. The gp120 protein bound to sulfatide (GalS), a sulfated glycolipid autoantigen implicated in sensory neuritis, and to the myelin associated glycoprotein (MAG), an autoantigen in demyelinating neuropathy. Binding of gp120 to MAG was inhibited by the HNK-1 antibody, which recognizes a sulfated glucuronic acid epitope, suggesting that the interaction involves carbohydrate determinants. Sulfatide and MAG are potential receptors for gp120 in peripheral nerve and may have a role in the neuropathy associated with HIV-1 infection. |
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| Keywords: | ELISA sulfatide myelin associated glycoprotein autoantigen neuropathy HIV-1 gp120 glycoprotein |
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