Effect of soluble H-2 antigens on the cytotoxic effect and adsorption of immune lymphocytes

Serologically active preparations of soluble H-2 antigens were obtained by extraction with 3 M KCl from ascites cells of leukemia L1210 (H-2^d) and sarcoma MCh-11 (H-2^b). These preparations had no specific effect on the cytotoxic action of immune lymphocytes on target cells in vitro and did not inhibit adsorption of lymphocytes on a monolayer of the corresponding target cells.Laboratory of Immunochemistry and Diagnosis of Tumors, N. F. Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow. Central Research Laboratory, Saratov Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR P. A. Vershilova.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 9, pp. 333–336, September, 1977.