The relevance of biomaterials to the prevention and treatment of osteoporosis |
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| Affiliation: | 1. Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain;2. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain;3. Dpto. Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Madrid, Spain;4. University of Erlangen-Nuremberg, Institute of Biomaterials, 91058 Erlangen, Germany;5. RMS Fundation, CH-2544 Bettlach, Switzerland;6. Hospital del Mar-IMIM, Department Internal Medicine, Universidad Autónoma de Barcelona, Barcelona, Spain;7. University of Duisburg-Essen, Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), D-45117 Essen, Germany;8. Servicio Cirugia Ortopedica & Traumatologia, Hospital La Paz, IdiPAZ, Universidad Autonoma Madrid, Madrid 28046, Spain;9. University of Zaragoza, Department of Surgery, E-50009 Zaragoza, Spain;10. Miguel Servet University Hospital, Department of Orthopaedic Surgery & Traumatology, Zaragoza 50009, Spain;11. Institute of Bioengineering of Catalonia IBEC, BaldiriReixac 15-20, Barcelona 08028, Spain;12. University Hospital Getafe, Division Geriatric Medicine, Madrid, Spain;1. Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany;2. Department of Trauma Surgery, University Hospital Giessen-Marburg GmbH, Giessen, Germany;3. Technische Universität Dresden, Centre for Translational Bone, Joint and Soft Tissue Research, Medical Faculty and University Hospital Carl Gustav Carus, Dresden, Germany;1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran;2. Cellular and Molecular Research Center (CMRC), Iran University of Medical Sciences, Tehran, Iran;3. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 14155-4777, Tehran, Iran;4. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran;5. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;6. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran;7. Shahid Beheshti University of Medical Sciences, School of Pharmacy, Department of Pharmaceutical Biotechnology, Iran;8. Institute of Materials Physics and Engineering, Department of Applied Science and Technology (DISAT), Politecnico di Torino, Torino, Italy;9. Unit of Dental Physical Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom;10. Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran;1. Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota;2. New Mexico Clinical Research & Osteoporosis Center, University of New Mexico School of Medicine, Albuquerque, New Mexico;1. Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, 100 Shi-Chuan 1st Road, Kaohsiung 80708, Taiwan;2. Department of Orthopaedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;3. Advanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, College of Engineering, Feng Chia University, Taichung 40724, Taiwan;4. Department of Orthopaedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan |
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| Abstract: | Osteoporosis is a worldwide disease with a very high prevalence in humans older than 50. The main clinical consequences are bone fractures, which often lead to patient disability or even death. A number of commercial biomaterials are currently used to treat osteoporotic bone fractures, but most of these have not been specifically designed for that purpose. Many drug- or cell-loaded biomaterials have been proposed in research laboratories, but very few have received approval for commercial use. In order to analyze this scenario and propose alternatives to overcome it, the Spanish and European Network of Excellence for the Prevention and Treatment of Osteoporotic Fractures, “Ageing”, was created. This network integrates three communities, e.g. clinicians, materials scientists and industrial advisors, tackling the same problem from three different points of view. Keeping in mind the premise “living longer, living better”, this commentary is the result of the thoughts, proposals and conclusions obtained after one year working in the framework of this network. |
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| Keywords: | Osteoporosis Biomaterials Ageing Bone |
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