Uric Acid Level and Erectile Dysfunction in Patients with Coronary Artery Disease |
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| Affiliation: | 2. Department of Cardiology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey;3. Department of Extracorporeal Hemocorrection, National Scientific Medical Research Center, Astana, Kazakhstan;4. Department of Nephrology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey;5. Dialysis Department, Centro Nacional de Salud Renal—Essalud, Lima, Peru;11. Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO, USA;12. Department of Medicine, Division of Nephrology, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey;2. Department of Molecular Medicine, Section of Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy;2. Department of Medicine, Karolinska Institutet, Stockholm, Sweden;3. Bayer Pharma AG, Berlin, Germany;4. Bayer AB, Solna, Sweden;5. Swedish Institute for Health Economics, Lund, Sweden;2. Department of Urology, University Vita-Salute San Raffaele, Milan, Italy;3. Research Doctorate Program in Urology, Magna Graecia University, Catanzaro, Italy;4. Department of Family Medicine, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa, Israel;5. Clalit Health Services, Haifa and Western Galilee District, Haifa, Israel;11. Institute of Psychology, University of Zurich, Zurich, Switzerland;12. Department of Urology, Ziekenhuis Amstelland, Amstelveen, The Netherlands;2. Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan;3. Department of Health Administration, Tuz Chi College of Technology, Hualien, Taiwan;4. Department of Statistics, National Cheng Kung University, Tainan, Taiwan;5. Department of Internal Section, Endocrinology and Metabolism, Kaohsiung Veterans General Hospital Tainan Branch, Tainan, Taiwan;2. Department of Urology, Men''s Health Center, Emory University, Atlanta, GA, USA;3. El Camino Urology Medical Group, Inc.Mountain View, CA, USA;4. Department of Surgery, University of Ottawa, Ottawa, ONCanada;5. Department of Urology, USF College of Medicine, Tampa, FL, USA;11. Erectile Restoration and Prosthetic Urology, Urology Centers of Alabama, Birmingham, AL, USA;12. Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA;8. Department of Urology, University of Maryland School of Medicine, Baltimore, MD, USA |
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| Abstract: | IntroductionErectile dysfunction (ED) is a frequent complaint of elderly subjects and is closely associated with endothelial dysfunction and cardiovascular disease (CVD). Uric acid is also associated with endothelial dysfunction, oxidative stress, and CVD, raising the hypothesis that an increased serum uric acid might predict ED in patients who are at risk for coronary artery disease (CAD).AimThis study aims to evaluate the association of serum uric acid levels with presence and severity of ED in patients presenting with chest pain of presumed cardiac origin.MethodsThis is a cross-sectional study of 312 adult male patients with suspected CAD who underwent exercise stress test (EST) for workup of chest pain and completed a sexual health inventory for men survey form to determine the presence and severity of ED. Routine serum biochemistry (and uric acid levels) were measured. Logistic regression analysis was used to assess risk factors for ED.Main Outcome MeasuresThe short version of the International Index of Erectile Function questionnaire diagnosed ED (cutoff score ≤ 21). Serum uric acid levels were determined. Patients with chest pain of suspected cardiac origin underwent an EST.ResultsOne hundred forty-nine of 312 (47.7%) male subjects had ED by survey criteria. Patients with ED were older and had more frequent CAD, hypertension, diabetes and impaired renal function, and also had significantly higher levels of uric acid, fibrinogen, glucose, C-reactive protein, triglycerides compared with patients without ED. Uric acid levels were associated with ED by univariate analysis (odds ratio = 1.36, P = 0.002); however, this association was not observed in multivariate analysis adjusted for estimated glomerular filtration rate.ConclusionSubjects presenting with chest pain of presumed cardiac origin are more likely to have ED if they have elevated uric acid levels. Solak Y, Akilli H, Kayrak M, Aribas A, Gaipov A, Turk S, Perez-Pozo SE, Covic A, McFann K, Johnson RJ, and Kanbay M. Uric Acid level and erectile dysfunction in patients with coronary artery disease. J Sex Med 2014;11:165–172. |
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