Targeted therapy in melanoma: the era of personalized medicine |
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| Institution: | 1. Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK;2. University of Manchester, Christie NHS Foundation Trust, Manchester, UK;1. Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran;2. Department of Biotechnology, University of Kashan, Kashan, Iran;1. Melanoma and Esophageal Oncology Unit, Veneto Institute of Oncology IOV – IRCCS, Padua, Italy;2. Medical Oncology of Melanoma, European Institute of Oncology, Milan, Italy;3. Department of Medical Sciences, Dermatologic Clinic, University of Torino, Torino, Italy;4. Department of Oncology, Surgery and Gastroenterology, University of Padova, Padua, Italy;5. Melanoma and Sarcoma Unit, Veneto Institute of Oncology IOV – IRCCS, Padua, Italy;1. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China;2. VA Nebraska-Western Iowa Health Care System and Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA |
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| Abstract: | Malignant melanoma is the most aggressive of all cutaneous tumours, with over 76, 000 new cases and 9700 deaths estimated for 2014 in the United States.1 In Canada, both the incidence and mortality of melanoma are increasing, with a risk of developing melanoma being 1 in 59 for men and 1 in 73 for women.2 The incidence of melanoma is higher in Australia, with a risk of 1 in 14 for males and 1 in 23 for females to age 85 reported for 2009.3 Although early melanoma can be managed surgically, until recently there have been few advances in the treatment of advanced melanoma. However, with the introduction of molecular targeted therapies, the landscape of melanoma treatment has changed dramatically in the past five years, resulting in improved survival rates for patients with metastatic disease. In this review, we will discuss the molecular basis and implementation for some of these novel treatments with particular emphasis on BRAF and BRAF inhibitors. |
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| Keywords: | Melanoma targeted therapy molecular BRAF TILs |
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