调强适形放疗联合替吉奥对无法手术老年胃癌患者免疫学指标及不良反应的影响

目的 研究调强适形放疗联合替吉奥对无法手术的老年胃癌患者免疫学指标及不良反应的影响。方法 选取2015年1月至2021年12月台州市肿瘤医院住院的老年胃癌患者100例，采用随机数字表法分为对照组(n=50)和观察组(n=50)。对照组进行替吉奥单一治疗，观察组在此基础上联合调强适形放疗。比较两组疾病控制率(disease control rate,DCR)以及两组治疗前后免疫学指标CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺的变化，对比两组不良反应发生率。结果 观察组的DCR显著高于对照组(P<0.05)。治疗后，两组患者CD8⁺显著低于治疗前(P<0.05),CD3⁺、CD4⁺、CD4⁺/CD8⁺显著高于治疗前(P<0.05)；治疗后观察组患者CD8⁺显著低于对照组(P<0.05),CD3⁺、CD...

Effect of moderated conformal radiotherapy combined with tegafur, gimeracil and oteracil on immunological parameters and adverse effects in inoperable elderly gastric cancer patients

Objective To investigate the effects of moderated conformal radiotherapy combined with tegafur, gimeracil and oteracil on immunological indicators and adverse effects in inoperable elderly patients with gastric cancer. Methods A total of 100 elderly patients with gastric cancer hospitalized in Taizhou Cancer Hospital from January 2015 to December 2021 were selected and divided into control group (n=50) and observation group (n=50) according to the random number table method. The control group was treated with tegafur, gimeracil and oteracil monotherapy, and the observation group was treated with combined intensity-modulated conformal radiotherapy on this basis. Compared the disease control rate (DCR), and the changes in immunological indicators CD3+, CD4+, CD8+ and CD4+/CD8+ before and after treatment between the two groups, and compared the incidence of adverse reactions between the two groups. Results DCR of the observation group was significantly higher than that of the control group (P<0.05). After treatment, CD8+ was significantly lower in both groups than before treatment (P<0.05), and CD3+, CD4+ and CD4+/CD8+ were significantly higher in both groups (P<0.05). After treatment, CD8+ was significantly lower in the observation group than that in the control group (P<0.05), and CD3+, CD4+ and CD4+/CD8+ were significantly higher than those in the control group (P<0.05). The incidence of adverse reactions was significantly lower in the observation group than that in the control group (P<0.05). Conclusion Intensity-modulated radiotherapy combined with tegafur,gimeracil and oteracil for inoperable elderly patients with gastric cancer can improve disease control with low adverse effects, and is worthy of widespread clinical application.