Injectable alginate hydrogels for cell delivery in tissue engineering |
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| Affiliation: | 1. INEB – Instituto de Engenharia Biomédica, Universidade do Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal;2. FEUP – Faculdade de Engenharia da Universidade do Porto, Departamento de Engenharia Metalúrgica e de Materiais, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal;3. ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal;1. Molecular Imaging Program at Stanford (MIPS), Department of Radiology, CA, USA;2. Department of Bioengineering, Stanford University, CA, USA;3. Department of Materials Science and Engineering, Stanford University, CA, USA;4. Department of Chemical Engineering, Queen''s University, Ontario, Canada;1. Instituto de Engenharia Biomédica (INEB), Rua do Campo Alegre, No. 823, 4150-180 Porto, Portugal;2. Faculdade de Engenharia, Universidade do Porto (FEUP), Rua Dr Roberto Frias s/n, 4200-465 Porto, Portugal;3. Centro de Biologia Ambiental/Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa (FCUL), Campo Grande s/n, 1749-016 Lisboa, Portugal;4. Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal;1. Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India;2. Biomaterials Science and Technology, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India;1. Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790-784, South Korea;2. Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790-784, South Korea;3. Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, South Korea;4. Department of Biomedical Science, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, South Korea;1. Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31 Hyoja-dong, Nam-gu, Pohang, Kyungbuk 790-784, Republic of Korea;2. Department of Bioengineering, University of Washington, Box 355061, Seattle, WA 98195, USA;3. Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 65 Landsdowne St. UP-5, Cambridge, MA 02139, USA;1. Parker H. Petit Institute for Bioengineering & Bioscience, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332, USA;2. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive NW, Atlanta, GA 30332, USA;3. Department of Mechanical Engineering, Stanford University, 496 Lomita Mall, Stanford, CA 94305, USA;4. George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive NW, Atlanta, GA 30332, USA |
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| Abstract: | Alginate hydrogels are extremely versatile and adaptable biomaterials, with great potential for use in biomedical applications. Their extracellular matrix-like features have been key factors for their choice as vehicles for cell delivery strategies aimed at tissue regeneration. A variety of strategies to decorate them with biofunctional moieties and to modulate their biophysical properties have been developed recently, which further allow their tailoring to the desired application. Additionally, their potential use as injectable materials offers several advantages over preformed scaffold-based approaches, namely: easy incorporation of therapeutic agents, such as cells, under mild conditions; minimally invasive local delivery; and high contourability, which is essential for filling in irregular defects. Alginate hydrogels have already been explored as cell delivery systems to enhance regeneration in different tissues and organs. Here, the in vitro and in vivo potential of injectable alginate hydrogels to deliver cells in a targeted fashion is reviewed. In each example, the selected crosslinking approach, the cell type, the target tissue and the main findings of the study are highlighted. |
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| Keywords: | Tissue engineering Regeneration Cell delivery Injectable Alginate |
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