The Role of Vitamin D in Chronic Obstructive Pulmonary Disease,Asthma and Other Respiratory Diseases |
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| Institution: | 1. Servicio de Medicina Interna, Hospital Universitario de Guadalajara, Guadalajara, Spain;2. Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Alcalá de Henares, Spain;3. Servicio de Neumología, Hospital Universitario de Guadalajara, Guadalajara, Spain;1. Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, UK;2. Asthma UK Centre for Applied Research, Blizard Institute, Queen Mary University of London, London, UK;3. Homerton University Hospital, Homerton Row, London, UK;4. Queen''s Hospital, Rom Valley Way, Romford, UK;5. Royal London Hospital, Whitechapel Road, London, UK;6. London School of Hygiene & Tropical Medicine, London, UK;7. Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester, UK;8. Medical Research Council, Asthma UK Centre in Allergic Mechanisms in Asthma, King''s College London, London, UK;1. Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío, CIBERES, IBIS, Sevilla, España;2. Servicio de Neumología, Hospital Universitario Ramón y Cajal, Madrid, España;3. Servicio de Neumología, Hospital Universitario de Cruces, CIBERES, Bilbao, España;4. Servicio de Neumología, Hospital Universitario La Paz-IdiP, Universidad Autónoma de Madrid, CIBERES, Madrid, España;5. Servicio de Neumología, Hospital de la Santa Creu i Sant Pau, Barcelona, España;6. Servicio de Neumología, Hospital Universitario Gregorio Marañón, Universidad Complutense, Madrid, España;7. Unidad de Neumología, Hospital Universitario de Granollers, Universitat Internacional de Catalunya, Granollers, Barcelona, España;1. Department of Internal Medicine, Division of Angiology, Medical University Graz, Austria;2. Institute for Medical Informatics, Statistics and Documentation, Medical University Graz, Austria;3. Department of Radiology, Division of Vascular and Interventional Radiology, Medical University Graz, Austria;1. Sunlight, Nutrition, and Health Research Center, P.O. Box 641603, San Francisco, CA 94164-1603, USA;2. Blizard Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London UK;3. Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei Blvd 98, Debrecen H-4032, Hungary;4. 2289 Highland Loop, Port Townsend, WA 98368, USA;1. Servicio de Medicina Interna, Hospital General Ticomán, Delegación Gustavo A. Madero, Mexico City, Mexico;2. Servicio de Medicina Interna, Hospital General 58, IMSS, Las Margaritas, Tlalnepantla, Estado de México, Mexico |
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| Abstract: | There has been a growing interest in recent years in the extraosseous effects of vitamin D.In this article, we review the physiology of vitamin D, the physiopathological effects associated with vitamin D deficit and the available evidence on its etiopathogenic role in respiratory diseases. Given the pleiotropic actions of vitamin D, it is biologically plausible that the deficit of this vitamin could play a pathogenic role in the development of various respiratory diseases. However, the many epidemiological studies that have shown an association between low vitamin D levels and a higher risk of developing various respiratory diseases, or a poorer prognosis if they do appear, were unable to show causality. Post hoc analyses of some clinical trials, particularly in chronic obstructive pulmonary disease (COPD) and asthma, appear to suggest that some patient subtypes may benefit from correction of a vitamin D deficit. In this respect, it would be interesting to determine if the interindividual differences found in the effect of vitamin D deficit and responses to correcting this deficit could be explained by the genetic variants involved in vitamin D metabolism. Ultimately, only appropriately designed clinical trials will determine whether 25-OH D supplements can prevent or improve the course of the various respiratory diseases in which an epidemiological association between prognosis and vitamin D deficit has been described. |
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| Keywords: | Vitamin D Chronic obstructive pulmonary disease Asthma Interstitial lung disease Tuberculosis Vitamina D Enfermedad pulmonar obstructiva crónica Asma Enfermedad pulmonar intersticial Tuberculosis |
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