Enhancement of antinociceptive effect of morphine by antidepressants in diabetic neuropathic pain model |
| |
| Affiliation: | 1. 1st Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, “AHEPA” Hospital, Greece;2. Internal Medicine and Diabetes Department, Salamis Naval Hospital, Salamis, Greece;3. Microcirculation Laboratory and Joslin–Beth Israel Deaconess Foot Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA |
| |
| Abstract: | BackgroundRecent studies have shown that influence of antidepressants on analgesic action of opioids is heterogeneous. The aim of this study was to investigate the effect of acute and repeated (21 days) antidepressant (amitriptyline, moclobemide and reboxetine) treatment on the antinociceptive action of morphine, an opioid agonist, in streptozotocin (STZ)-induced neuropathic pain model.MethodsThe studies were performed on the male Wistar rats. The changes in nociceptive thresholds were determined by using mechanical stimuli (the Randall–Selitto and the von Frey tests). Diabetes was induced by intramuscular administration of STZ.ResultsIn this work we report that acute as well as repeated per os administration of antidepressants (amitriptyline, moclobemide and reboxetine) significantly potentiated the antihyperalgesic effect of morphine in STZ-induced neuropathic pain model.ConclusionCombination therapy, such as classical antidepressants (amitriptyline, moclobemide) with opioids, or agents with noradrenaline reuptake inhibition and μ-opioid receptor activation could be a new target for research into treatment of painful diabetic neuropathy. |
| |
| Keywords: | Diabetes Streptozotocin-induced hyperalgesia Amitriptyline Morphine Pain |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
