Three-dimensional printing of strontium-containing mesoporous bioactive glass scaffolds for bone regeneration |
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| Affiliation: | 1. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, People’s Republic of China;2. Department of Orthopaedics, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, 600 Yishan Road, Shanghai 200233, People’s Republic of China;3. School of Materials Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, People’s Republic of China;1. Barts & The London School of Medicine and Dentistry, Institute of Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK;2. Unit of Dental Physical Sciences, Barts and The London, Queen Mary University of London, Mile End Road, London E1 4NS, UK;1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, Portugal;2. ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal;3. Centre for Biomaterials and Tissue Engineering, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield S10 2TA, United Kingdom |
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| Abstract: | In this study, we fabricated strontium-containing mesoporous bioactive glass (Sr-MBG) scaffolds with controlled architecture and enhanced mechanical strength using a three-dimensional (3-D) printing technique. The study showed that Sr-MBG scaffolds had uniform interconnected macropores and high porosity, and their compressive strength was ∼170 times that of polyurethane foam templated MBG scaffolds. The physicochemical and biological properties of Sr-MBG scaffolds were evaluated by ion dissolution, apatite-forming ability and proliferation, alkaline phosphatase activity, osteogenic expression and extracelluar matrix mineralization of osteoblast-like cells MC3T3-E1. The results showed that Sr-MBG scaffolds exhibited a slower ion dissolution rate and more significant potential to stabilize the pH environment with increasing Sr substitution. Importantly, Sr-MBG scaffolds possessed good apatite-forming ability, and stimulated osteoblast cells’ proliferation and differentiation. Using dexamethasone as a model drug, Sr-MBG scaffolds also showed a sustained drug delivery property for use in local drug delivery therapy, due to their mesoporous structure. Therefore, the 3-D printed Sr-MBG scaffolds combined the advantages of Sr-MBG such as good bone-forming bioactivity, controlled ion release and drug delivery and enhanced mechanical strength, and had potential application in bone regeneration. |
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| Keywords: | 3-D printing Mesoporous bioactive glass Scaffolds Strontium Bone regeneration |
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