Comparison of the effects of Matricaria chamomila (Chamomile) extract and mefenamic acid on the intensity of premenstrual syndrome |
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| Affiliation: | 1. International Branch, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Midwifery and Reproductive Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Department of Pharmacognosy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Department of Biostatics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;1. Pharmaceutical Sciences Research Center and Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran;2. Research Office for the History of Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;3. Vascular and Degenerative Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;4. Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran;5. Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran;6. Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran;1. Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, 7021 Zarzouna, Tunisia;2. Laboratoire de Nutrition et Physiologie Animale, Institut Supérieur de Biotechnologie de Béja, Avenue Habib Bourguiba, B.P., 382-9000 Béja, Tunisia;3. INSERM U773 Centre de Recherche Biomédicale, Faculté de Médecine X. Bichat, 75018 Paris, France;1. Applied Organic Chemistry Department, Chemical Industries Research Division, National Research Centre, 33 EL Buhouth St., Dokki, Giza 12622, Egypt;2. Department of Chemistry, College of Science, Sultan Qaboos University, PO Box 36, PC 123, Muscat, Oman;1. Midwifery Group, Nursing and Midwifery Faculty, Tabriz University of Medical Sciences, Tabriz, Iran;2. Midwifery Group, Research center of health effective social factors, Nursing and Midwifery Faculty, Tabriz University of Medical Sciences, Tabriz, Iran;3. Health Services Management Research Center, Nursing and Midwifery Faculty, Tabriz University of Medical Sciences, Tabriz, Iran;4. Students’ research committee, Nursing and Midwifery Faculty, Tabriz University of Medical Sciences, Tabriz, Iran;1. School of Pharmacy and Applied Science, La Trobe Institute of Molecular Sciences, La Trobe University, Edwards Road, Bendigo 3550, Australia;2. Physiology Department, Medical School, Universiti Teknologi Mara, Selangor, Malaysia |
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| Abstract: | The study aimed to compare the effects of Chamomile Extract and Mefenamic acid (MA) on the intensity of Premenstrual syndrome (PMS) symptoms.This study was a clinical randomized double blind trial, carried out with 90 students living in the dorms of Iran. The participants filled the daily forms about the intensity of PMS for two consecutive months. Once the definitive diagnosis of PMS was made, the participants were divided into two groups, each receiving either Chamomile capsule 100 mg or MA 250 mg three times a day. Intensity reduction of emotional symptoms was significantly higher among Chamomile Extract-users (30.1 ± 26.6 and 33.4 ± 25.3 percent) than that among MA-users (11.6 ± 25.7 and 10.7 ± 26.8 percent) after two cycles intervention (p < 0.001). Intensity reduction of physical symptoms was not significantly different (p > 0.05) among groups. Consumption of Chamomile seems to be more effective than MA in relieving the intensity of PMS associated symptomatic psychological pains. |
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| Keywords: | Chamomile Mefenamic acid Premenstrual syndrome |
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