Scaffolds for tissue engineering of cardiac valves |
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| Affiliation: | 1. Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;2. University of Kansas School of Medicine, 3901 Rainbow Blvd, Kansas City, KS 66160, USA;1. Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada;2. Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada;3. Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada;1. Stem Cell and Molecular Biology Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, TN, India;2. Tissue Culture Laboratory, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojappura, Trivandrum, Kerala 695012, India;3. Trivitron Innovation Centre, Department of Engineering Design, Indian Institute of Technology Madras, Chennai 600036, TN, India;4. Conducting Polymer laboratory, Department of Physics, Indian Institute of Technology, Madras, Chennai 600036, TN, India |
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| Abstract: | Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform – the so-called scaffold – is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research. |
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| Keywords: | Heart valve Tissue engineering Scaffold Fiber Hydrogel |
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