Fatty liver disease |
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Affiliation: | 1. Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;2. South African Medical Research Council Centre for Tuberculosis Research, Cape Town, South Africa;3. Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Cape Town, South Africa;1. LABioMed at Harbor UCLA Medical Center, Department of Pathology, Torrance, CA 90509, USA;2. VA Medical Center, Department of Medicine, Long Beach, CA, USA |
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Abstract: | It is now widely accepted that fatty liver disease is one of the commonest causes of cirrhosis and liver cell cancer (even in the absence of cirrhosis), in its own right as well as being an important cofactor for the progression of other diseases e.g. viral hepatitis. While much work has been done on developing non-invasive techniques for assessing liver disease, the liver biopsy remains the benchmark against which these tests have to be validated as well as providing information that cannot be obtained in any other way. This review describes the histological features that alcoholic and non-alcoholic liver disease have in common (e.g. fatty change, ballooning and Mallory–Denk bodies) as well as identifying those that are more characteristic of each of them (e.g. nuclear vacuolation in non-alcoholic fatty liver disease and a florid fatty liver hepatitis in alcoholic fatty liver disease). Recent developments in the assessment of the degree of fatty change are described. |
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