南通市319例鼻咽癌住院患者临床资料分析

目的 对南通市肿瘤医院2002—2017年鼻咽癌病例临床资料进行分析,了解南通地区鼻咽癌分布流行特点,为鼻咽癌早诊筛查和制定综合防治措施提供参考信息。方法 收集南通市肿瘤医院2002年1月—2017年12月肿瘤登记数据库中319例鼻咽癌患者病例资料,对鼻咽癌年龄、性别、临床症状、病程、住院次数和病理类型等变量进行统计分析。结果 319例鼻咽癌患者中,男性221例(69.28%),女性98例(30.72%)。年龄最小为16岁,最大为83岁,中位年龄55岁;患者主要集中在40~69岁。住院病程中位时间为5.02个月,超过6个月者占50.47%。患者临床症状中,43.57%为鼻部症状,40.44%伴发有颈部肿物。TNM分期中,T1~T2共124例(38.87%),T3~T4共103例(32.29%);N0共33例(10.34%),N1~N2共176例(55.17%);远处复发转移(M1)为48例(15.05%)。临床分期以中晚期为主,Ⅲ期最多(115例,36.05%),Ⅳ期次之(78例,37.62%)。病理组织类型以非角化型未分化癌居多(98.43%)。住院1次者占20.06%,住院2~5次者为53.61%,平均住院4.48±3.71次。早期病例和中晚期病例的5年观察生存率分别为77.50%和72.96%,差异有统计学意义(P＜0.05)。结论 住院鼻咽癌患者以男性为主、中老年人为主,非角化型未分化癌为主且以中晚期病例为主。鼻咽癌的早诊早治应引起重视。

Clinical analysis of 319 patients with nasopharyngeal carcinoma in Nantong City

Objective The aim of this study was to analyze the clinical data of nasopharyngeal carcinoma cases in Nantong Tumor Hospital from 2002 to 2017,to understand the distribution and epidemic characteristics of nasopharyngeal carcinoma in Nantong,and to provide reference information for early diagnosis and screening of nasopharyngeal carcinoma and the formulation of comprehensive prevention and treatment measures. Methods The case data of 319 nasopharynx cancer patients were collected in the tumor registration database of Nantong Tumor Hospital from January 2002 to December 2017,and the distribution of age,sex,symptoms,course of disease,number of hospitalizations and pathological types etc.of nasopharyngeal carcinoma were statistically analyzed. Results Among 319 nasopharynx cancer patients,221 were male(69.28%)and 98 female(30.72%).The minimum age was 16 years old,the maximum age was 83 years old,and the median age was 55 years old.The patients were mainly 40-69 years old.The median duration of hospitalization was 5.02 months,and those over 6 months accounted for 50.47%.Among the clinical symptoms,43.57% were nasal symptoms,and 40.44% were accompanied by neck tumors.In TNM staging,124 cases(38.87%)were T1-T2,103 cases(32.29%)were T3-T4,33 cases(10.34%)were N0,176 cases(N1-N2)(55.17%),and 48 cases(15.05%)were distal recurrence and metastasis(M1).The clinical staging was mainly in the middle and late stages:Phase Ⅲ was the most common(115 cases,36.05%),followed by phase IV(78 cases,37.62%).The most common type of pathological tissue was non-keratinizing undifferentiated carcinoma(98.43%).Distribution of hospitalizations times:20.06% were hospitalized once,53.61% were hospitalized 2-5 times,and the average of hospitalization time was(4.48±3.71).The 5-year observed survival rates of early cases and middle and late cases were 77.50% and 72.96%,respectively,with statistical significance(P＜0.05). Conclusion The majority of hospitalized nasopharynx cancer patients are males,middle-aged and elderly,and the majority of non-keratinized undifferentiated cancer patients are middle and late stage patients.Early diagnosis and treatment of nasopharynx cancer should be attention.