MMP-14 can serve as a prognostic marker in patients with supraglottic cancer |
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Authors: | Huiyan Zhang Ming Liu Yanan Sun Jianguang Lu |
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Institution: | (1) Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, 150086 Harbin, People’s Republic of China;(2) Department of Otorhinolaryngology, Head and Neck Surgery, The 211 hospital of PLA, Harbin, People’s Republic of China |
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Abstract: | The purpose of this study was to examine the expression of MMP-14, 15 and 16 (MT1, MT2 and MT3-MMP) in supraglottic carcinoma
and to explore their clinical significance. Expression of MMP-14, 15 and 16 was examined using RT-PCR and immunohistochemistry
methods in samples from 85 cases of supraglottic carcinoma. Results showed that both mRNA and protein expression of MMP-14,
15 and 16 were increased in supraglottic carcinoma tissues compared to expression in control adjacent non-neoplastic tissues
(P < 0.05). Expression of MMP-14, but not MMP-15 and MMP-16, was significantly increased in the T3 and neck nodal metastasis
groups compared with the T1–2 group and the group without nodal metastasis at both mRNA and protein levels (P < 0.05). Expression of MMP-14 mRNA and protein was also higher in tumors of patients with stage III–IV disease compared to
patients with clinical stage I–II tumors (P < 0.05). Kaplan–Meier survival curves showed that the groups with high MMP-14 protein expression had a poorer prognosis than
patients in the groups with weak or negative expression of MMP-14 protein (P < 0.05). In conclusion, MMP-14 may play an important role in the progression of supraglottic carcinoma and may be a novel
prognostic factor for patients with supraglottic carcinoma.
Huiyan Zhang and Ming Liu are co-first authors. |
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Keywords: | Supraglottic carcinoma Membrane-type matrix metalloproteinases Prognosis |
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