Inhibitors of nitric oxide synthase block carbon monoxide-induced increases in cGMP in retina

We investigated the changes in glutamate release from the ipsi- and contra-lesional medial vestibular nucleus (MVN) following unilateral labyrinthectomy (UL) by in vivo microdialysis study. The concentration of glutamate in the ipsi-lesional MVN was decreased until 4 h. Twelve hours after UL, the concentration of glutamate was restored back to the basal level, after which the release did not show any change between 24 and 48 h post-UL. In contrast, the concentration of glutamate in the contra-lesional MVN, which increased immediately after UL, decreased gradually to the basal level until 3-4 h post-UL, followed by no further change. The difference in the glutamate concentration between ipsi- and contra-lesional MVN increased immediately after UL and gradually decreased accompanied by a reduction in the frequency of nystagmus, although spontaneous nystagmus had not disappeared by the time the imbalance of glutamate release diminished. These results suggest that the imbalance of glutamate release between bilateral nuclei induced the nystagmus, and the change in release is concerned with the rapid development of vestibular compensation.