胸部炎性肌纤维母细胞瘤的诊断与治疗

目的探讨胸部炎性肌纤维母细胞瘤(IMT)的病因、临床诊断、治疗方法及预后,以进一步提高对本病的认识。方法回顾性分析2005年4月~2011年7月我院收治的12例胸部炎性肌纤维母细胞瘤患者的临床资料,其中男性9例,女性3例;年龄36~81岁,平均年龄60.08岁。5例行肺叶切除+纵膈淋巴结清扫术,2例行肺叶切除术,肺叶局部切除术、纵隔肿物切除术及肋骨切除术各1例,行保守治疗2例。结果手术患者术后均平稳恢复,病理检查均未发现淋巴结转移;所有患者均随访,随访时间2月~5年,无肿瘤复发或转移征象。保守治疗患者1例随访3月肿瘤无明显变化,另1例患者病变基本消失。结论胸部炎性肌纤维母细胞瘤是少见的良性肿瘤,但少数具有复发倾向及恶变潜能,明确诊断主要依靠病理检查结果。治疗以手术切除为主,可辅以其它治疗。所有IMT患者治疗后应密切随访。

Diagnosis and treatment of inflammatory myofibroblastic tumor of the chest

Objective To explore the causes,clinic diagnosis,treatment and prognosis of inflammatory myofibroblastic tumor(IMT) of the chest.Methods The clinical data of 12 patients with IMT were retrospectively analyzed including 9 male and 3 female patients aged 36 to 81 years(mean 60.08 years).Five patients underwent pulmonary lobectomy and mediastinal lymph node dissection,1 had partial lobectomy,1 had mediastinal tumor resection and costectomy,and 2 received conservative treatment.Results All the surgical patients recovered after surgery without lymph node metastasis detected by pathological examinations.In the follow-up lasting for 2 months to 5 years,no recurrence or metastasis occurred in these cases.In the 2 cases having conservative treatment,the tumor remained unchanged in one case at 3 month of follow-up and disappeared in the other case.Conclusion IMT in the chest is a rare benign tumor with a low incidence rate and malignancy.Pathological examination is reliable for definite diagnosis.Surgical operation is the primary the rapeutic approach.All IMT patients should be closely followed up after the treatment.