100例习惯性流产患者的病因及绒毛染色体分析

目的探讨习惯性流产与绒毛染色体异常及其环境因素的关系。方法将在我院就诊的100例早孕期习惯性流产患者作为研究组，加例正常早孕行人工流产术的患者作为对照组，对两组患者进行绒毛细胞染色体分析，并由专人询问、登记相关资料。结果研究组绒毛染色体异常发生率为53．00％。显著高于对照组（10．00％）；研究组染色体异常中以常染色体三体居多，占50．94％；研究组患者长期被动吸烟的发生率（50．00％）显著高于对照组（32．50％）；研究组中长期接触电脑、电视的患者显著高于对照组。结论绒毛染色体异常是导致孕早期习惯性流产的主要原因，孕妇长期被动吸烟、长期接触电脑、电视是引起习惯性流产的高危因素。

Analysis of fetal chromosomal karyotyp and etiology in 100 cases with early habitual abortion

Objective:To investigate the relationship between fetal chromosomal karyotype and early habitual abortion,and study the effect of the environmental factors involved in habitual abortion.Methods:The study group was consisted of 100 women with early habitual abortion.The control group was consisted of 40 women with normal pregnancies.We used their chorion to analyse the chromosome karyotype,meanwhile question protocol were specially used in the above cases,the results were statistically analyzed.Results:The rate of the abnormal chorion chromosome in study group was 53.00%,significantly higher than in the control group(10.00%).Among 53 cases with karyotype disorder,27 cases of trisomy syndrome take 50.94% of the cases.The female exposed factor such as long time and low dose radiation,passive smoking seem to be related with habitual abortion.Conclusion: Abnormal chorion chromosome is a main reason of early habitual abortion.Environmental factors might play a role in the pathogenesis of habitual abortion.