MAO inhibition and the effects of centrally administered LSD,serotonin, and 5-methoxytryptamine on the conditioned avoidance response in rats |
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| Authors: | Walter C. Prozialeck Wolfgang H. Vogel |
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| Affiliation: | (1) Department of Pharmacology, Thomas Jefferson University, 1020 Locust Street, 19107 Philadelphia, PA, USA |
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| Abstract: | Pretreatment with the MAO-inhibitors iproniazid, clorgyline, or deprenyl abolishes the effects of LSD on the conditioned avoidance response (CAR) in rats. The effects of serotonin (5-HT) and 5-methoxytryptamine (5-MT) are greatly potentiated by these substances. Brain levels of LSD are not affected by MAO inhibition whereas levels of 5-HT and 5-MT are significantly elevated. It is postulated that the decreased behavioral response to LSD is the result of  MAO inhibitor-induced changes whereas the increased response of 5-HT and 5-MT results from increased brain levels of these compounds. |
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| Keywords: | LSD Serotonin 5-Methoxytryptamine MAO inhibitors Conditioned avoidance response |
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