雄激素与绝经后女性冠状动脉粥样硬化性心脏病相关研究进展

冠状动脉粥样硬化性心脏病发病率存在着明显的年龄差异,女性在绝经前发病率较低,绝经后迅速增加,几乎达到绝经前的4倍.这种现象提示绝经后女性冠状动脉粥样硬化性心脏病的发生可能与性激素水平的改变有关.近期关于绝经后雄激素水平改变与冠状动脉粥样硬化性心脏病的关系已成为研究的热点,但由于雄激素的确切作用机制较为复杂,所以其对冠状动脉粥样硬化性心脏病的作用仍未完全明确.现就目前雄激素与绝经后女性冠状动脉粥样硬化性心脏病关系的研究进展做一综述,并对雄激素能否用于绝经后女性冠状动脉粥样硬化性心脏病的治疗进行展望.

Research Progress in Relationship between Androgens and Coronary Heart Disease in Postmenopausal Women

The incidence rates of coronary heart disease differ greatly between age groups,and premenopausal women have a low incidence.However,it is well known that coronary heart disease incidence increases in women’s after menopause.Postmenopausal women’s morbidity is four times higher than premenopausal.This phenomenon is related to the different levels of female sex hormones.The role of androgens in postmenopausal women’s cardiovascular health is not completely understood.In this paper we have reviewed progress in defining the relationship between androgens and coronary heart disease in postmenopausal women.